The Taxoid Constituents of the Roots ofTaxus wallichiana*

Abstract

The essential oil yields of the leaves and flowers of V. agnuscastus f. rosea ranged from 0.33 % to 0.52 % (the reproducibility is 0.01 %; n = 3). The composition of essential oils is shown in Table 1. The oils were composed of monoterpenes and sesquiterpenes. The principal constituents of the monoterpenoid fractions were limonene, cineole, sabinene, and aterpineol, while the major sesquiterpenes were J3-caryophyllene, p-gurjunene, cuparene, and globulol. Some of these main components compare well with the results in other reports on the essential oil of V. agnus-castus (6, 7).

LC‐ESI‐MS analysis of taxoids from the bark of Taxus wallichiana

“…Our earlier study on the profiling of taxoids in the needles of T. wallichiana using MS/MS techniques had revealed the presence of several taxane alkaloids (Madhusudanan et al, 2001a). Moreover, we have so far isolated and characterized about 30 taxoids of different structural types from the needles, leaves, stem bark, heartwood and roots of T. wallichiana Chattopadhyay et al, 1994Chattopadhyay et al, , 1996aChattopadhyay et al, -e, 1997Chattopadhyay et al, , 1998Chattopadhyay et al, , 1999a. Continuing the work we have tried to profile the taxoid content in the extracts of stem bark of the Himalayan yew.…”

Natural Sources of Taxol

“…fastigiata) greatest taxol yield was in April and least in February but, "aurea" varieties yield traces of taxol and shoot growth occurs between May and July [33]. The roots of T. wallichiana gave nine taxoids; taxol, pentaacetoxytaxadiene, baccatin III and IV, 1hydroxybaccatin, a C-oxygenated taxoid, taxusin, 7-xylosyl-10-deacetyltaxol, and a rearranged taxoid [34]. Concentration of taxanes in bark and foliage showed decreasing gradient from the stem base to tip of branches and the decreased concentration was due to higher taxanes concentration in the phloem tissues and thickness of the inner bark from the base to branch tip.…”

Taxoid from the needles of the Himalayan yew Taxus wallichiana with cytotoxic and immunomodulatory activities

“…Over 300 taxoids have been isolated from the genus Taxus and excellent reviews have appeared on this important class of molecules. 2,3 The needles, 4,3,5,6 stem bark, 7-9 heartwood, 10 roots, 11 and seeds 12 of Taxus wallichiana were separately investigated yielding several structurally unique taxoids.…”