The targeting of anionized polyvinylpyrrolidone to the renal system

Kodaira, Hiroshi; Tsutsumi, Yasuo; Yoshioka, Yasuo; Kamada, Haruhiko; Kaneda, Yoshihisa; Yamamoto, Yoko; Tsunoda, Shin-ichi; Okamoto, Takayuki; Mukai, Yohei; Shibata, Hiroko; Nakagawa, Shinsaku; Mayumi, Tadanori

doi:10.1016/j.biomaterials.2003.10.097

Cited by 58 publications

(42 citation statements)

References 10 publications

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“…These results concur with the hypothesis of Kodaira et al 13 on the renal targeting potential of anionic carboxylated polymers. Of the two polymers, 41 kDa PG-Tr exhibited a better renal retention profile than 17 kDa PG-Tr, as shown by a higher and longer accumulation in the kidneys (Figure 2).…”

Section: Discussionsupporting

confidence: 93%

“…As previously suggested, 13 an active proximal tubular reuptake process may be crucial in the accumulation of small-sized, anionized carboxylated polymeric carriers in the kidneys. Our results also support an earlier finding 13 that altered renal functions and hemodynamics in the diabetic state may affect the active proximal tubular reuptake process and the renal accumulation of renal targeting agents. Consequently, the performance of small-sized carboxylated carriers may be affected by the pathological state of the kidneys.…”

Section: Discussionmentioning

confidence: 64%

“…The renal retention of 17 kDa PG-Tr observed in this study may indicate an involvement of post-glomeruli process such as active reuptake of small-sized anionic carboxylated polymers by the proximal tubules. 13 Meanwhile, the favorable renal retention of 41 kDa PG-Tr suggests an extravasation of PG-Tr from the renal vasculature and the accumulation of PG-Tr in the renal parenchymal tissues. Our study on the renal accumulation pattern of fluorescence-labeled 41 kDa PG (PG-AF) shows an uptake and localization of PGs in the epithelial cells of the proximal tubules at 2 and 6 h after an iv administration to the normal rats.…”

Section: Discussionmentioning

confidence: 99%

“…13 The authors proposed that the efficiency of renal targeting of anionic carboxylated polymers may be significantly influenced by the degree of carboxylation of the polymer body. Contradicting findings were observed in the present study.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 A peak renal tissue localization of a radiolabeled anionized polyvinylpyrrolidone (PVP) derivative, 10 kDa carboxylated PVP, was observed at 3 h after an intravenous (iv) injection. 13 This selective renal tissue accumulation suggests that the carboxylated polymers exhibit renal targeting properties. Based on this, we hypothesize that carboxylated polypeptides could be used as a renal targeting carrier for therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

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Advances in biotechnology, proteomics, and genomics, as well as the deeper understanding of the molecular and cellular bases of pathophysiological states, have allowed the development of novel drugs such as proteins, peptides, and nucleic acids as therapeutic strategies of the future. Their application, however, requires sophisticated drug delivery systems which can be used to alter the pharmacokinetics and release characteristics of drugs, and to increase tissue specificity and biocompatibility. In this context, polymers provide the most promising avenue in drug release control due to their favorable, adjustable characteristics, and possibilities for further modification. Advances in the biomedical sciences have had a significant impact on the design and development of new and intelligent drug delivery systems for more controlled and targeted drug application. This review summarizes the status quo of polymer use for drug delivery with a special focus on structure–property relationships and gives overviews of various polymers, the relevant parameters in drug delivery and the most promising trends in the future.

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Current Progress in Nanotechnology Applications for Diagnosis and Treatment of Kidney Diseases

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Significant progress has been made in nanomedicine, primarily in the form of nanoparticles, for theranostic applications to various diseases. A variety of materials, both organic and inorganic, have been used to develop nanoparticles with promise to achieve improved efficacy in medical applications as well as reduced systemic side effects compared to current standard of care medical practices. In particular, this article highlights the recent development and application of nanoparticles for diagnosing and treating nephropathologies.

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The targeting of anionized polyvinylpyrrolidone to the renal system

Cited by 58 publications

References 10 publications

Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats

Renal targeting potential of a polymeric drug carrier, poly-L-glutamic acid, in normal and diabetic rats

Polymers in Drug Delivery—State of the Art and Future Trends

Current Progress in Nanotechnology Applications for Diagnosis and Treatment of Kidney Diseases

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