Current Progress in Nanotechnology Applications for Diagnosis and Treatment of Kidney Diseases

Lee, Sue Hyun; Lee, Jung Bok; Bae, Min Soo; Balikov, Daniel A.; Hwang, Amy; Boire, Timothy C.; Kwon, Il Keun; Sung, Hak‐Joon; Yang, Jae Won

doi:10.1002/adhm.201500177

Cited by 20 publications

(11 citation statements)

References 128 publications

(95 reference statements)

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“…The filtration initially occurs at the interface of glomerulus and Bowman’s capsule. Filtered molecules or nanoparticles need to pass through three filtration layers, the endothelium, glomerular basement membrane (GBM), and foot processes of the podocytes [79]. The endothelium provides an initial physical barrier that contains a pore size of 80–100 nm in diameter.…”

Section: Discussion and Outlookmentioning

confidence: 99%

Folate-mediated chemotherapy and diagnostics: An updated review and outlook

Bai

Zhang

et al. 2017

Journal of Controlled Release

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Folate receptor (FR) is highly expressed in many types of human cancers, and it has been actively studied for developing targeted chemotherapy and diagnostic agents. Tremendous efforts have been made in developing FR-targeted nanomedicines and nanoprobes and translating them into clinical applications. This article provides a concise review on the latest development of folate-mediated nanomedicines and nanoprobes for chemotherapy and diagnostics with an emphasis on in vivo applications. The cellular uptake mechanisms, pharmacokinetics (PK), administration routes and major challenges in FR-targeted nanoparticles are discussed.

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Section: Discussion and Outlookmentioning

confidence: 99%

Folate-mediated chemotherapy and diagnostics: An updated review and outlook

Bai

Zhang

et al. 2017

Journal of Controlled Release

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“…Recently, gold nanoparticles have been commonly applied for surface plasmon resonance scattering since they can resonantly scatter visible and near-infrared light due to their surface plasmon oscillation [ 78 ]. In addition, they are easy to prepare, readily bioconjugated, and have low cytotoxicity, making them suitable for biomolecular labeling and targeting [ 79 ]. It is reported that the conjugated nanoparticles tended to aggregate together, inducing a greatly enhanced surface plasmon resonance scattering compared to unconjugated nanoparticles [ 80 ].…”

Section: Nanotechnology-based Detection and Diagnostic Methodsmentioning

confidence: 99%

“…In the past few decades, nanotechnology has brought new techniques to cancer diagnosis [ 36 , 38 , 132 , 133 ]. The performance parameters of nanoparticles-such as biocompatibility, function-specific size and shape, blood circulation half-life, and targeting to specific cell surface molecules-can be controlled by modulating their fabrication materials, methods or surface chemistry, making nanoparticles a promising diagnostic material [ 79 ]. The present review article has critically introduced nano-based detection strategies for oral cancers, and summarized various kinds of nanomaterials, sample types, and the characteristic of each technique in Table 1 .…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Nanotechnology: a promising method for oral cancer detection and diagnosis

et al. 2018

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Oral cancer is a common and aggressive cancer with high morbidity, mortality, and recurrence rate globally. Early detection is of utmost importance for cancer prevention and disease management. Currently, tissue biopsy remains the gold standard for oral cancer diagnosis, but it is invasive, which may cause patient discomfort. The application of traditional noninvasive methods-such as vital staining, exfoliative cytology, and molecular imaging-is limited by insufficient sensitivity and specificity. Thus, there is an urgent need for exploring noninvasive, highly sensitive, and specific diagnostic techniques. Nano detection systems are known as new emerging noninvasive strategies that bring the detection sensitivity of biomarkers to nano-scale. Moreover, compared to current imaging contrast agents, nanoparticles are more biocompatible, easier to synthesize, and able to target specific surface molecules. Nanoparticles generate localized surface plasmon resonances at near-infrared wavelengths, providing higher image contrast and resolution. Therefore, using nano-based techniques can help clinicians to detect and better monitor diseases during different phases of oral malignancy. Here, we review the progress of nanotechnology-based methods in oral cancer detection and diagnosis.

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“…In the case of iron (Xu et al, 2014;Baiu et al, 2015) and gold anti-GD2 NPs (Jiao et al, 2016), the authors concurred with high tumor specificity targeting and suggested the use of anti-GD2 NPs not only as anticancer nanomedicines per se but also as suitable diagnostic nanodevices in NB therapy. Theragnosis (simultaneous diagnosis and treatment) is nowadays gaining relevance in nanotechnology (Lee et al, 2015). Given that metallic NPs can be monitored by MRI, they might be very useful in NB, where diagnosis and staging are crucial (Chen et al, 2018a).…”

Section: Targeted Nanomedicines For Neuroblastomamentioning

confidence: 99%

Therapeutic Opportunities in Neuroblastoma Using Nanotechnology

Rodríguez-Nogales

Noguera

Couvreur

et al. 2019

J Pharmacol Exp Ther

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Neuroblastoma (NB) is the most common extracranial solid tumor preferentially occurring in preschoolers. Its characteristic aggressiveness and heterogeneous clinical behavior are especially visible in relapsed or refractory cases and hamper therapeutic success. Although the introduction of novel antitumor agents, such as dinutuximab, isotretinoin, irinotecan, or I-131-metaiodobenzylguanidine, has increased survival rates, the situation in high-risk NB remains dismal. Moreover, treatment is particularly aggressive in these patients, leading to short-and long-term toxicities. The extensive research performed using nanotechnology in recent decades has prompted its application as a therapeutic alternative to overcome some of the common limitations of conventional chemotherapy. Nevertheless, the therapeutic role of nanomedicine in pediatric tumors like NB is not fully elucidated, and to date, only albuminbound paclitaxel nanoparticles have reached clinic stages. In this review, we summarize the current therapeutic strategies for NB with special attention to the use of nanomedicine. We also highlight the preclinical studies on passive and active targeting nanodelivery of therapeutics in experimental NB models.

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Current Progress in Nanotechnology Applications for Diagnosis and Treatment of Kidney Diseases

Cited by 20 publications

References 128 publications

Folate-mediated chemotherapy and diagnostics: An updated review and outlook

Folate-mediated chemotherapy and diagnostics: An updated review and outlook

Nanotechnology: a promising method for oral cancer detection and diagnosis

Therapeutic Opportunities in Neuroblastoma Using Nanotechnology

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