The T cell receptor subsets of lymphocytes in bronchoalveolar lavage in patients with active pulmonary tuberculosis

St, Uh; Sy, Ki; Gi, Lim; Sh, Moon; Sw, Jeong; Ht, Kim; Yh, Kim; Cs, Park

doi:10.1016/s0954-6111(98)90283-9

Respiratory Medicine

1998

DOI: 10.1016/s0954-6111(98)90283-9

|View full text |Cite

The T cell receptor subsets of lymphocytes in bronchoalveolar lavage in patients with active pulmonary tuberculosis

Uh St¹,

Ki Sy²,

Lim Gi³

et al.

Abstract: gamma/delta Lymphocytes do not appear to have as much meaning in patients as they do in animal studies.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1999

2008

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Approximately 2% of T-lymphocytes are found in the peripheral blood, whereas nearly 10% reside in the lungs [3]. In active tuberculosis (TB), memory T-cells clonally expand upon antigen encounter and are recruited to the site of the infection [4][5][6][7][8][9][10]. These MTB-specific memory Tcells produce interferon (IFN)-c [11] and other cytokines of the type-1 T-helper cell-type immune response [12].…”

mentioning

confidence: 99%

Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot

Jafari

Ernst²,

Strassburg³

et al. 2008

European Respiratory Journal

View full text Add to dashboard Cite

Lymphocytes are crucial in the immune defence against Mycobacterium tuberculosis (MTB) infection. The aim of the present study was to ascertain whether or not MTB-specific lymphocytes are selectively compartmentalised in the lungs of patients with minimal active pulmonary tuberculosis (PTB).Patients with smear-negative MTB-culture-confirmed PTB were prospectively recruited. Differential cell counts, immunophenotyping with monoclonal antibodies directed against the cell surface markers CD4, CD8, CD4CD45RA, CD4CD45R0, CD38, human leukocyte antigen DR, CD19, CD3, CD57 and CD16 and MTB-specific enzyme-linked immunospot assays of peripheral blood mononuclear cells and bronchoalveolar lavage (BAL) mononuclear cells with 6-kDa early secretory antigenic target and culture filtrate protein 10 were performed.Among 12 patients with culture-confirmed smear-negative PTB, no differences were found in the distribution of total CD4 or CD8 T-cells in peripheral blood or BAL fluid (BALF). Activated human leukocyte antigen-DR-positive cells, as well as memory CD4CD45R0-positive T-cells, were expanded among cells of the BALF. Compared with a group of control patients with alternative pulmonary pathologies, there was no significant difference in lymphocyte subpopulations. However, 6-kDa early secretory antigenic target-and culture filtrate protein 10-specific lymphocytes were more concentrated, with a median BALF:peripheral blood ratio of 9.9 and 8.9, respectively, in patients with PTB.Mycobacterium tuberculosis-specific T-cells are highly selectively compartmentalised at the site of infection in active pulmonary tuberculosis.

show abstract

mentioning

confidence: 99%

Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot

Jafari

Ernst²,

Strassburg³

et al. 2008

European Respiratory Journal

View full text Add to dashboard Cite

show abstract

?? T cells, their T cell receptor usage and role in human diseases

Kabelitz

Wesch

Hinz

1999

Springer Semin Immunopathol

View full text Add to dashboard Cite

Natural T, γδ, and NK Cells in Mycobacterial,Salmonella,and Human Immunodeficiency Virus Infections

Jason¹,

Buchanan²,

Archibald³

et al. 2000

J INFECT DIS

View full text Add to dashboard Cite

NK cells, gammadelta T cell antigen receptor chain-positive cells, and CD3(+)CD16/56(+) (natural T [NT]) cells are involved in innate immunity and immunoregulation; however, their role in clinical infection is not well defined. Cytofluorometric analysis was used to examine peripheral blood from bacteremic, nonbacteremic, and healthy human immunodeficiency virus (HIV)-positive and -negative persons in Malawi, Africa. Mycobacteremia was associated with a higher proportion of CD3(+)CD8(-) gammadelta cells (median, 16.6% vs. 0.7% for all other cells; P<.001), and Salmonella bacteremia was associated with a higher proportion of NT cells (4.3% vs. 2.2%; P=. 002). HIV plasma RNA levels were weakly positively correlated with NT cells (rs=.39; P=.002), NK cells (rs=.38; P=.003), and gammadelta cells (rs=.43; P<.001). Compared with patients who survived, patients who died had a higher percentage of NT cells (3.7% vs. 1. 9%; P=.017) and a higher percentage of NT cells that spontaneously produced interferon-gamma (2.4% vs. 1.2%; P=.035). The data support the clinical relevance of gammadelta and NT cells in mycobacterial, Salmonella, and HIV infections and of NT cells in mortality.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

The T cell receptor subsets of lymphocytes in bronchoalveolar lavage in patients with active pulmonary tuberculosis

Abstract: gamma/delta Lymphocytes do not appear to have as much meaning in patients as they do in animal studies.

Cited by 3 publications

References 21 publications

Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot

Local immunodiagnosis of pulmonary tuberculosis by enzyme-linked immunospot

?? T cells, their T cell receptor usage and role in human diseases

Natural T, γδ, and NK Cells in Mycobacterial,Salmonella,and Human Immunodeficiency Virus Infections

Contact Info

Product

Resources

About