?? T cells, their T cell receptor usage and role in human diseases

Kabelitz, Dieter; Wesch, Daniela; Hinz, Thomas

doi:10.1007/bf00815178

Cited by 31 publications

(27 citation statements)

References 186 publications

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“…These values may appear much lower than those previously reported by studies which showed that g/d TCR-positive cells represent about 17% of all CD3 positive cells in the red pulp of the spleen. [33][34][35] However, the same studies reported that, in periarteriolar sheaths, g/d TCR expressing cells were rare. Thus, the apparent discrepancy between our results and previously reported data is caused by the different approaches used to analyze and report the frequency of g/d TCR-positive cells.…”

Section: Discussionmentioning

confidence: 99%

Flow cytometric analysis of normal and reactive spleen

Colovai

Giatzikis

et al. 2004

Modern Pathology

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Spleen is surgically removed for both non-neoplastic and neoplastic pathologies. A significant proportion of splenectomy specimens require distinguishing between reactive and neoplastic conditions (eg lymphoma). To establish a 'normal' reference range for the spleen lymphocyte subsets, fresh samples of benign, reactive spleens obtained from adult patients (N ¼ 12) and samples of normal spleen obtained from cadaveric transplant donors (N ¼ 14) were analyzed using three-and four-color flow cytometry. Study of pan-B, -T, and -NK marker expression revealed that the frequency of T cells is higher and that of B cells is lower in reactive (nonneoplastic) compared to normal (cadaveric) spleen. Furthermore, our study established a frame of reference for cell markers commonly used for immunophenotyping of lymphoma, and identified discrete lymphocyte subsets, such as early plasma cells and T cells carrying the phenotype of the NK/T subset. These results will facilitate an accurate interpretation of the flow cytometric analysis of human spleen lymphocytes.

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Section: Discussionmentioning

confidence: 99%

Flow cytometric analysis of normal and reactive spleen

Colovai

Giatzikis

et al. 2004

Modern Pathology

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“…104 Gamma-δ T cells, which are activated by HSP, have been found to be elevated in ocular BD. 106 They are also responsive to viral or bacterial phosphoantigens 107 and superantigens 108 that are produced by infectious organisms such as streptococci, 109 which are implicated in the pathogenesis of BD. The TNF promoter allele TNF-1031C has been recently reported to be associated with BD susceptibility in Caucasoid patients, 110 and the co-expression of the TNF-β*2 allele with HLA-B*51 has also been found to contribute to the severity of ocular disease.…”

Section: Behçet's Diseasementioning

confidence: 99%

Cytokines and Chemokines in Uveitis - Is there a Correlation with Clinical Phenotype?

Ooi¹,

Galatowicz²,

Calder³

et al. 2006

Clinical Medicine & Research

133

118

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“…During childhood, however, the PB TCRgd þ Tcell repertoire is strikingly shaped so that Vg9/Vd2 cells clearly dominate in adults. 118 Studies have shown that Vd1 and Vd2 repertoires become restricted with age leading to the appearance of oligoclonal Vd1 þ and Vd2 þ cells in blood and intestine. 119 TCRgd þ T cells are evenly distributed throughout human lymphoid tissues, but there is preferential expression of particular Vd segments in specified anatomical localizations.…”

Section: Introductionmentioning

confidence: 99%