The Synthesis of Taurine from Sulfate VIII. A Constitutive Enzyme in Mammal

Martin, William G.; Truex, C. R.; Tarka, Stanley M.; Hill, Lenora J.; Gorby, William G.

doi:10.3181/00379727-147-38387

Cited by 16 publications

(2 citation statements)

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“…CSA is formed from cysteine (Cys) (De la Rosa and Stipanuk, 1983), which is related to the transsulfuration pathway of Met metabolism (Martin et al, 1974;Cooper, 1983;Rao et al, 1990). Although Met is generally involved in Tau biosynthesis, the biosynthesis of Tau by transsulfuration is reduced under certain metabolic conditions and an alternate biosynthetic mechanism takes place; Martin et al (1974) have in fact shown that a 3'-phosphoadenosine-5'-phosphosulfate (PAPS) sulfotransferase is present in rat tissues, including the brain. This enzyme catalyzes the synthesis of Tau from Ser and sulfate.…”

Section: Discussionmentioning

confidence: 99%

Effects of ageing on the content in sulfur-containing amino acids in rat brain

Benedetti

Russo

Marrari

et al. 1991

J. Neural Transmission

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Concentrations of the sulfur-containing amino acids methionine, homocysteic acid, cysteic acid and taurine were measured in brain structures of young and old Wistar rats in an attempt to establish a possible link between the increase in oxidative stress with ageing and changes in tissue levels of these amino acids. Contrary to data reported by others, in all brain structures of young and old rats homocysteic acid levels could not be quantified. Compared with young rats, in old animals taurine and methionine concentrations significantly decreased in striatum and cortex; decreased taurine levels were also found in nucleus accumbens and cerebellum and lower concentrations of methionine were found in midbrain, hippocampus and pons-medulla. Cysteic acid levels either did not change or significantly increased in cortex and hippocampus. These results are discussed taking into account the biosynthesis of sulfur-containing amino acids in rat brain and the decrease in glutathione in relation to oxidative stress with ageing. Changes in aspartic acid, glutamic acid, serine, glutamine, glycine and GABA concentrations with ageing were also determined in the same brain structures and were in good agreement with those previously reported (Strolin Benedetti et al., 1990 a, b).

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Section: Discussionmentioning

confidence: 99%

Effects of ageing on the content in sulfur-containing amino acids in rat brain

Benedetti

Russo

Marrari

et al. 1991

J. Neural Transmission

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show abstract

“…The activity of this erizyme, termed the inorganic pathway of taurine biosynthesis to distinguish it from the transsulfuration pathway where the origin of taurine-S is organic ( I 5 ) , is stable in a B6-deficiency while the decarboxylase activity of the transsulfuration pathway is not (16). This alternate pathway of taurine biosynthesis in the rat (17) may therefore be of significance to the animal due to its universal presence, as compared to the limited tissue occurrence of the organic taurine pathway enzymes (18).…”

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confidence: 99%