The synthesis of new potential photosensitizers. Part 3. Tetraphenylporphyrin esters of profens

Kuś, Piotr; Kozik, Violetta; Rojkiewicz, Marcin; Sochanik, Aleksander; Szurko, Agnieszka; Kempa, Marta; Kozub, Patrycja; Rams-Baron, Marzena; Jarzembek, Krystyna; Stefaniak, Marta; Sakowicz, Julian

doi:10.1016/j.dyepig.2015.01.011

Cited by 10 publications

(2 citation statements)

References 17 publications

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“…Apart from CPs and APs, porphyrin PSs having no net charge have been explored as possible PDT agents under in vitro conditions (Figure 1.6.3.1). 97,[244][245][246][247][248][249][250][251][252][253] The most commonly used neutral porphyrins are 5,10,15,20-(tetraphenyl) porphyrin (H2TPP), [244][245][246][247][248][249][250] and 5,10,15,20tetra-(4-hydroxyphenyl) porphyrin (THPP). [254][255][256][257][258][259][260] The tetra-symmetric chlorin 5,10,…”

Section: Neutral Porphyrin Pssmentioning

confidence: 99%

Porphyrins in Photodynamic Therapy: A Review

Sharma,

Sengupta

2023

Preprint

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Porphyrins have emerged as versatile and highly effective photosensitizers in the field of photodynamic therapy (PDT). This promising therapeutic approach relies on the light-induced generation of reactive oxygen species (ROS) by photosensitizing agents. This comprehensive review explores the multifaceted role of porphyrins across various PDT applications, encompassing anticancer PDT, immuno-PDT, antimicrobial PDT, and antiviral PDT. Porphyrins exhibit the potential to serve as organic supramolecular platforms for developing various photosensitizers (PSs) tailored for specific PDT modalities. The exceptional capacity of porphyrins to specifically accumulate in target cancer cells or microorganisms, their proficiency in generating ROS upon exposure to light, and their capability to amass within cell mitochondria to facilitate apoptosis establish porphyrins as invaluable assets in a wide array of therapeutic applications. Ongoing research endeavours and clinical investigations continually unveil the vast potential of porphyrin-based PDT in combatting a wide range of diseases, spanning from cancer and infections to viral ailments. Furthermore, porphyrins hold promise in addressing drug-resistant cancers and antimicrobial resistance through non-invasive PDT, offering efficient alternatives to commercially available PDT drugs. In the context of advanced cancer management, porphyrin-based PDT offers the prospect of combinatorial therapy, enabling a sequence of immunogenic post-PDT actions that can effectively overcome anticancer resistance and tackle metastatic cancers. The future of PDT appears promising, with porphyrin scaffolds expected to play pivotal roles in advancing this field.

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Section: Neutral Porphyrin Pssmentioning

confidence: 99%

Porphyrins in Photodynamic Therapy: A Review

Sharma,

Sengupta

2023

Preprint

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“…The use of the above-mentioned photosensitizers also has other disadvantages such as the problem of being excreted very slowly from the human organism. The patient undergoing photodynamic therapy is exposed to several weeks’ sensitivity to the Sun’s rays [ 28 , 29 , 30 , 31 , 32 ]. Most of the complex compounds show low absorption of radiation, therefore, when synthesizing new coordination compounds, ligands are carefully selected, or the existing complex compounds are skillfully modified.…”

Section: Introductionmentioning

confidence: 99%

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

Pobłocki

Drzeżdżon

Kostrzewa

et al. 2021

IJMS

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Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.

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