A Ru(II)-p-cymene compound bearing naproxen-pyridineamide. Synthesis, spectroscopic studies, computational analysis and in vitro anticancer activity against lung cells compared to Ru(II)-p-cymene-naproxen and the corresponding drug ligands

Tabares, Julie Pauline Gaitan; Santos, Rodrigo Luis Silva Ribeiro; Cassiano, Jefferson Luiz; Zaim, Marcio H.; Honorato, João; Batista, Alzir A.; Teixeira, Sarah Fernandes; Ferreira, Adilson Kleber; Viana, Rommel B.; Martínez, Sandra Quispe; Stábile, Antonio Carlos; Silva, Denise de Oliveira

doi:10.1016/j.ica.2019.01.030

Cited by 14 publications

(2 citation statements)

References 114 publications

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“…Taking into account the dissociation of the two complexes in DMSO, it is probable that the cell growth inhibitory activity has contributions from several species generated in the biological medium [34]. In general, however, a slight increase in the activity upon metalation of the two ligands was observed.…”

Section: Cytotoxicity Assaysmentioning

confidence: 99%

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes

et al. 2022

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The reaction of [Ru2Cl2(μ-Cl)2(η6-p-cymene)2] with two thiosemicarbazones obtained by the condensation of N-(4-methoxybenzyl) thiosemicarbazide and 1,4-hydroxy-3-methoxyphenyl)ethan-1-one (HL1) or 2-fluoro-4-hydroxybenzaldehyde (HL2) was studied. The cationic complexes of formula [RuCl(η6-p-cymene)(HL)]+ were isolated as solid chloride and trifluoromethylsulfate (TfO) salts. A study of the solid state and NMR spectra suggests the presence in the material of two isomers that differ in the configuration in the iminic bond, C2=N3, of the coordinated thiosemicarbazone in the triflate salts and only the E isomer in the chloride. An X-ray study of single crystals of the complexes supports this hypothesis. The thiosemicarbazone ligand coordinates with the ruthenium center through the iminic and sulfur atoms to form a five-membered chelate ring. Furthermore, the isolation of single crystals containing the thiosemicarbazonate complex [Ru2(μ-L2)2(η6-p-cymene)2]2+ suggests the easy labilization of the coordinated chloride in the complex. The redox behavior of the ligands and complexes was evaluated by cyclic voltammetry. It seems to be more difficult to oxidize the complex derived from HL1 than HL2. The ability of the complexes to inhibit cell growth against the NCI-H460, A549, and MDA-MB-231 lines was evaluated. The complexes did not show greater potency than cisplatin, although they did have greater efficacy, especially for the complex derived from HL1.

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Section: Cytotoxicity Assaysmentioning

confidence: 99%

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes

et al. 2022

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“…O complexo formado é estável e tem grande aplicabilidade como catalisador ou precursor para a síntese de outros complexos de rutênio, os quais possuem aplicações diversas (Esquema 3). [27][28][29][30][31][32] Esquema 3. Algumas aplicações do complexo meio sanduíche [Ru(p-cimeno)Cl2]2.…”

Section: Introductionunclassified

Design e síntese de potenciais ligantes quirais

Hayashi

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Agradeço primeiramente à minha família por todo o suporte para eu ter chego até esta etapa da minha vida, e por me aguentar nesses meses de isolamento por causa do COVID-19.À minha amiga Bianca, que sempre me apoiou nos momentos mais difíceis, e que não foram poucos.Ao meu orientador Caio, que graças aos incentivos dele, seja por reuniões de grupo, exercícios de síntese ou reuniões de literatura, me ajudou no meu desenvolvimento e aprofundamento na pesquisa de química orgânica sintética.Aos membros da banca, prof. Dr. Pilli, prof. Dr. Pastre e a Dra. Cristiane Schwalm, pelas discussões no exame de qualificação e defesa de dissertação e pelas sugestões valiosas para esta versão final.Aos meus colegas de laboratório, sejam do laboratório do Caio: Jefferson, Eduardo (este tendo que me aguentar desde a graduação),

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Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action

Gouda

Beshr

Almalki

et al. 2019

Bioorganic Chemistry

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A Ru(II)-p-cymene compound bearing naproxen-pyridineamide. Synthesis, spectroscopic studies, computational analysis and in vitro anticancer activity against lung cells compared to Ru(II)-p-cymene-naproxen and the corresponding drug ligands

Cited by 14 publications

References 114 publications

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes

Synthesis, Characterization, and Cytotoxicity Studies of N-(4-Methoxybenzyl) Thiosemicarbazone Derivatives and Their Ruthenium(II)-p-cymene Complexes

Design e síntese de potenciais ligantes quirais

Arylpropionic acid-derived NSAIDs: New insights on derivatization, anticancer activity and potential mechanism of action

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