The synthesis of monocyclic and bicyclic molecules and their antioxidant properties

Bekfelavi, Esen Yıldız; Kuş, Nermin Şimşek

doi:10.1016/j.molstruc.2019.04.034

Cited by 6 publications

(4 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antioxidant molecules are so important because they can be kept under control by the unstable free radicals, which are produced always in the human body 49,50 . Thus, they can hinder some common diseases such as cancer and cardiovascular so the synthesis of antioxidant molecules and examine their antioxidant properties are important topic in the literature 51–53 . In this work, the antioxidant activities of synthesized molecules were examined as used DPPH free radical scavenging activity and ferrous ions (Fe 2+ ) chelating activity, which is known methods in the literature 54–56 .…”

Section: Resultsmentioning

confidence: 99%

“…49,50 Thus, they can hinder some common diseases such as cancer and cardiovascular so the synthesis of antioxidant molecules and examine their antioxidant properties are important topic in the literature. [51][52][53] In this work, the antioxidant activities of synthesized molecules were examined as used DPPH free radical scavenging activity and ferrous ions (Fe 2+ ) chelating activity, which is known methods in the literature. [54][55][56] In the beginning, the highest concentration (800 μg/ml) of all synthesized molecules were prepared for specify of active compounds in methods (DPPH or Iron chelating) using for investigation of antioxidant capacity (Table 5).…”

Section: Antioxidant Activitiesmentioning

confidence: 99%

See 1 more Smart Citation

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Yılmaz

2021

J Chinese Chemical Soc

View full text Add to dashboard Cite

New series of Schiff bases have been synthesized from the reaction between cyclohepta-2,4,6-trien-1-ylmethanamine and different aldehydes, and characterized via using 1 H NMR, 13 C NMR, FTIR spectroscopy, and GC-MS. After the successful synthesis, the in situ catalytic activity of all Schiff bases have been examined for the Suzuki C C cross-coupling reactions using phenylboronic acid, aryl bromides, and PdCl 2 as a catalyst. Before starting these investigations, reaction conditions were optimized using different bases and solvents. At the end of these reactions, the best efficiency was obtained in Et 3 N and EtOH. In addition to catalytic investigations, antioxidant activities of all synthesized Schiff bases were examined using DPPH and Iron (Fe 2+ ) chelation methods, and IC 50 values were calculated. While many molecules show various amounts of antioxidant activity, especially molecules 8e and 8g showed the best activity compared to butylated hydroxytoluene (BHT) and butylated hydroxyanisole (BHA), which were used as positive controls, in DPPH and Iron chelating methods, respectively.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Antioxidant Activitiesmentioning

confidence: 99%

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Yılmaz

2021

J Chinese Chemical Soc

View full text Add to dashboard Cite

show abstract

“…After incubation for half an hour in the dark, UV measurements at 517 nm were taken. According to the decrease in absorbance value, antioxidant activity was calculated using the formula below (Equation 1 [1,29–33]

\vcenter{\openup.5em\halign{$\displaystyle{#}$\cr \char37 \ {\rm DPPH}\ {\rm Scavenging}=({\rm A}{_{{\rm o}}}- {\rm A}{_{{\rm s}}}/{\rm A}{_{{\rm o}}})\times 100\hfill\cr}}

…”

Section: Methodsmentioning

confidence: 99%

“…According to the decrease in absorbance value, antioxidant activity was calculated using the formula below (Equation 1). [1,[29][30][31][32][33] % DPPH Scavenging ¼ ðA o À A s =A o Þ � 100…”

Section: Dpph Free Radical Scavenging Activitymentioning

confidence: 99%

Synthesis of Schiff Bases and Secondary Amines with Indane Skeleton; Evaluation of Their Antioxidant, Antibiotic, and Antifungal Activities

Erdoğan

Yılmaz

Çevik

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

In this study, Schiff bases were synthesized by utilizing the reaction of 4‐ and 5‐aminoindane with substituted benzaldehydes. After the reduction of isolated Schiff bases with NaBH4, the corresponding secondary amine derivatives were obtained. The structures of all synthesized molecules were confirmed by 1H‐NMR, 13C‐NMR, FTIR, and ESI‐MS. Antioxidant activities of all synthesized molecules were investigated by DPPH method, and IC50 values were calculated. In addition, antibacterial activities of targets were investigated by the well diffusion method, and then MIC99 values were calculated. While only four of the sixteen synthesized molecules showed a high level of antioxidant activity, all of the molecules exhibited biological activity against gram‐positive and gram‐negative bacteria to varying degrees. In addition, all the synthesized molecules showed high antifungal activity. In antioxidant capacity studies, the IC50 values of 2‐(((2,3‐dihydro‐1H‐inden‐5‐yl)amino)methyl)‐6‐methoxyphenol (4d) and 2‐(((2,3‐dihydro‐1H‐inden‐4‐yl)amino)methyl)‐6‐methoxyphenol (7d) were determined to be 18.1 µg and 35.1 µg, respectively, and these values are much stronger than BHT (butylated hydroxytoluene) and BHA (butylated hydroxyanisole) used as positive controls. The fact that targets have the same core structure with different substituents has revealed a good structure‐activity relationship.

show abstract

Novel halo-molecules; synthesis, structure elucidation, mechanism, and antioxidant activity

et al. 2021

View full text Add to dashboard Cite

The synthesis of monocyclic and bicyclic molecules and their antioxidant properties

Cited by 6 publications

References 36 publications

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Synthesis of new Schiff bases; Investigation of their in situ catalytic activity for Suzuki CC coupling reactions and antioxidant activities

Synthesis of Schiff Bases and Secondary Amines with Indane Skeleton; Evaluation of Their Antioxidant, Antibiotic, and Antifungal Activities

Novel halo-molecules; synthesis, structure elucidation, mechanism, and antioxidant activity

Contact Info

Product

Resources

About