The synthesis of chemotherapeutic agents. II.

Abstract

In this paper, the second of a series, the continuation of a study of certain thio and dithio compounds related to 5,5′‐diacetamido‐8,8′‐diquinolyl disulfide is described. Of the fourteen sulfur compounds synthesized and characterized, which are described in this paper, twelve are new. Several of these have undergone screening tests for antimalarial activity. Incidental to the syntheses reported new methods are described for the preparation of 2,3‐ and 4‐chloro isomers of 5‐nitro‐quinoline.