A series of novel chromonyl-containing α-aminophosphonates were synthesized by a one-pot reaction from 3-formylchromones, substituted aromatic amines, and dialkylphosphites. Synthesized compounds were characterized by elemental analysis, and 1 H NMR and IR spectroscopy. Single crystal x-ray diffraction data of compound 6e was obtained, and analysis indicates that the crystal belongs to triclinic system with space group P-1, a = 9.4200(4) Å, b = 10.5970 (6) Å, c = 12.3506(5) Å, α = 84.178(2) • , β = 73.5830(10) • , γ = 68.2720(10) • . V = 1098.59(9) Å 3 , Z = 2, µ = 0.163 mm −1 , F(000) = 456, R[F 2 >2σ(F 2 )] = 0.0835, ωR(F 2 ) = 0.2328.