This review describes the most frequently reported synthetic methods for N-heterocyclyl-α-aminophosphonic acids and their mono-or di-esters bearing a heterocyclic or heteroaryl system at the nitrogen atom, as well as methods for the synthesis of α-(azaheterocyclyl)phosphonates. The Pudovik and Kabachnik-Fields reactions are the main pathways for construction of these features besides other miscellaneous methods.
This review describes a comprehensive account of methods which are commonly applied for the synthesis of α-heterocyclic/heteroaryl α-aminophosphonic acids and their esters. In the following order, protocols based on the methodologies listed below are discussed: (a) Pudovik reaction; (b) Kabachnik-Fields reaction and (c) Miscellaneous Methods.
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