The Synthesis and Properties of 6-Chloropurine and Purine¹

Abstract

6073neutral fraction (495 mg.) separated from it. The benzenesoluble part of the neutral fraction (340 mg.) dissolved in a small volume of benzene was poured onto a column of 20 g.of Fisher alumina and the chromatogram developed with absolute petroleum ether. The first 10 fractions (each 50 ml.) yielded 137 mg. of colorless oil which was converted into the trinitrobenzene complex. This compound was repeatedly crystallized from ethanol to a constant melting point of 157°; the yield of the analytically pure sample was 30 mg. This melting point is 20°h igher than the melting point of l-methyl-7-ethylphenanthrene trinitrobenzolate and no depression of melting point was observed on admixture of an authentic sample of pimanthrene trinitrobenzolate which melted also at 157°. The sample was decomposed by chromatography on a small column of alumina and the crystalline hydrocarbon sublimed for infrared and ultraviolet spectrum. These were identical with the spectra of an authentic specimen of pimanthrene.

Analytical detection and biological assay of antileukemic drug using gold nanoparticles

“…6 -Mercaptopurine (6-MP) was synthesized according to a modified, previously reported procedure 32,33 and the purity of the sample ascertained by comparing it with the commercial sample obtained from Aldrich. The reaction scheme is given below (Scheme.2)…”

Synthesis and Antioxidant Evaluation of Some New Pyrazolopyridine Derivatives

“…Pyrazolo [3,4-a]pyrimidines are of considerable chemical and pharmacological importance as purine analogues [22,23]. Various related compounds of these also have antitumor, anti-leukemic activities.…”

Synthesis of N-7-Substituted Purines from Imidazole Precursors

“…The yields for the last step of these syntheses varied from 40 to 70%. On the other hand, compounds 6a and 6b, thus far described in the literature [23], were obtained via catalytic dehalogenation of already prepared purine derivatives (i.e. chloropurines) in yields of 60-80% (given for the last step as well).…”