Analytical detection and biological assay of antileukemic drug using gold nanoparticles

Selvaraj, V.; Alagar, M.; Hamerton, Ian

doi:10.1016/j.electacta.2006.07.016

Cited by 23 publications

(14 citation statements)

References 47 publications

(12 reference statements)

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“…CCAM loaded with 6-MP shows a band at 3424 cm 21 corresponding to the stretching frequency of -NH group. Other absorption bands at 1611 and 1407 cm 21 were due to C5C and C-N stretching vibrations and there is a corresponding absorption band at 1275 cm 21 (C5S stretch) [30].…”

Section: Ftir Spectra Of Ccammentioning

confidence: 99%

Characteristics and degradation of chitosan/cellulose acetate microspheres with different model drugs

Zhou

Chen

2008

Front. Mater. Sci. China

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In this study, chitosan/cellulose acetate microspheres (CCAM) were prepared by W/O/W emulsification and solvent evaporation as a drug delivery system. The microspheres were spherical, free-flowing and non-aggregated. The CCAM had good flow and suspension ability. The loading efficiency of different model drugs increased with the increasing hydrophobicity of the drug. The loading efficiency of 6-mercaptopurine (6-MP) was more than 30% whereas that of ranitidine hydrochloride (RT) or acetaminophen (ACP) was only 10%. The pH values of solution affected the swelling ability of CCAM and the relative humidity had little effect on the characteristics of CCAM when it was not more than 75%. The CCAM system had a good effect on the controlled release of different model drugs. However, the release rate became slower with the increase of the hydrophobicity of drugs. The release rate of CCAM loaded with hydrophilic RT was almost 60% during 48 h and the release rate of CCAM loaded with hydrophobic drug of 6-MP was not more than 30%. In the meantime, the CCAM system was degradable in vitro and the degradation rate was faster in lysozyme solution than that in the medium of PBS. So the CCAM system was a degradable promising drug delivery system especially for hydrophobic drugs.

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Section: Ftir Spectra Of Ccammentioning

confidence: 99%

Characteristics and degradation of chitosan/cellulose acetate microspheres with different model drugs

Zhou

Chen

2008

Front. Mater. Sci. China

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“…Nanoparticles, with their well-controlled shapes, sizes, high surface to volume ratio, and magnetic properties1 are now widely used as drug delivery systems for the treatment of a range of systemic, oral, pulmonary,2 and kidney diseases. Magnetite nanoparticles, in particular iron oxide nanoparticles, are inorganic materials that can be coated with various polymers and/or loaded with therapeutic agents embedded in polymeric matrices 3.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Dorniani¹,

Hussein²,

Kura³

et al. 2013

DDDT

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BackgroundIron oxide nanoparticles are of considerable interest because of their use in magnetic recording tape, ferrofluid, magnetic resonance imaging, drug delivery, and treatment of cancer. The specific morphology of nanoparticles confers an ability to load, carry, and release different types of drugs.Methods and resultsWe synthesized superparamagnetic nanoparticles containing pure iron oxide with a cubic inverse spinal structure. Fourier transform infrared spectra confirmed that these Fe3O4 nanoparticles could be successfully coated with active drug, and thermogravimetric and differential thermogravimetric analyses showed that the thermal stability of iron oxide nanoparticles coated with chitosan and 6-mercaptopurine (FCMP) was markedly enhanced. The synthesized Fe3O4 nanoparticles and the FCMP nanocomposite were generally spherical, with an average diameter of 9 nm and 19 nm, respectively. The release of 6-mercaptopurine from the FCMP nanocomposite was found to be sustained and governed by pseudo-second order kinetics. In order to improve drug loading and release behavior, we prepared a novel nanocomposite (FCMP-D), ie, Fe3O4 nanoparticles containing the same amounts of chitosan and 6-mercaptopurine but using a different solvent for the drug. The results for FCMP-D did not demonstrate “burst release” and the maximum percentage release of 6-mercaptopurine from the FCMP-D nanocomposite reached about 97.7% and 55.4% within approximately 2,500 and 6,300 minutes when exposed to pH 4.8 and pH 7.4 solutions, respectively. By MTT assay, the FCMP nanocomposite was shown not to be toxic to a normal mouse fibroblast cell line.ConclusionIron oxide coated with chitosan containing 6-mercaptopurine prepared using a coprecipitation method has the potential to be used as a controlled-release formulation. These nanoparticles may serve as an alternative drug delivery system for the treatment of cancer, with the added advantage of sparing healthy surrounding cells and tissue.

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“…The present work is the continuation of our previous work with gold nanoparticles (Selvaraj et al, 2006). The objective of present study is to ascertain the isoniazid containing PET-co-PLA nanocapsules for drug delivery behaviour and to determine quantitative effect of gold nanoparticles on the average size, the encapsulation efficiency, the morphology and the rate of drug release under different conditions.…”

Section: Introductionmentioning

confidence: 92%

Studies on controlled release of gold/tuberculosis drug complex entrapped polyethylene terephthalate-co-polylactic acid polymer nanoparticles

Kumar¹,

Selvaraj

Alagar

2011

IJNP

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Polyethylene terephthalate-polylactic acid copolymer (PET-co-PLA) was prepared by using bis (2-hydroxyethyl terephthalate) and lactic acid oligomer with manganese antimony glycoxide as a catalyst. Isoniazid (INH) containing polyethylene terephthalate-polylactic acid copolymer (PET-co-PLA) nanocapsules were prepared in the presence and absence of gold nanoparticles via the W/O/W emulsification solvent-evaporation method. The morphologies of prepared nanocapsules were observed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). The structure of copolymer was determined using nuclear magnetic resonance spectroscopy. The morphology of the prepared nanocapsules (PIA, containing PET-co-PLA, isoniazid and gold nanoparticles) differs substantially because of the presence of gold nanoparticles. From SEM and TEM measurements, the average size of the polymer nanocapsules and gold nanoparticles were found to be in range of 230-260 nm and 18-20 nm respectively. Polymer nanocapsules with gold show a prolonged controlled release with higher encapsulation efficiency compared to that of polymer nanocapsules in the absence of gold nanoparticles. It may be due to the more entrapping efficiency of gold and less diffusivity of drugs from the nanocapsules. Studies on controlled release of gold/tuberculosis drug complex 315Reference to this paper should be made as follows: Sathishkumar, K., Selvaraj, V. and Alagar, M. (2011) 'Studies on controlled release of gold/tuberculosis drug complex entrapped polyethylene terephthalate-copolylactic acid polymer nanoparticles', Int. (India). His research areas include synthesis of nanomaterials (nanoparticles, polymers and conductive polymer-carbon nanotubes composites), characterisation and applications in fuel cells, sensors and drug delivery.Muthukaruppan Alagar is a Professor in the Department of Chemical Engineering, Anna University, Chennai (India). He has more than 25 years of teaching and research experience. He has authored more than 100 research publications. His research areas include synthesis of nanoparticles for fuel cell applications, nanoparticles in drug delivery, siliconised epoxy resins, epoxy clay hybrid nanocomposites.

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Analytical detection and biological assay of antileukemic drug using gold nanoparticles

Cited by 23 publications

References 47 publications

Characteristics and degradation of chitosan/cellulose acetate microspheres with different model drugs

Characteristics and degradation of chitosan/cellulose acetate microspheres with different model drugs

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system

Studies on controlled release of gold/tuberculosis drug complex entrapped polyethylene terephthalate-co-polylactic acid polymer nanoparticles

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