The synthesis and antituberculosis activity of 5-alkynyl uracil derivatives

Design and synthesis of novel phthalocyanines as potential antioxidant and antitumor agents starting with new synthesized phthalonitrile derivatives

“…The solvent was evaporated to afford colorless needle crystals. Colorless needle crystals; yield 57%; mp 173 C; IR (KBr) n/cm À1 : 3320 (2NH); 1 Synthesis of 1,4-dioxo-5,10-dipropyl-1,4,5,10-tetrahydro phenazine-2,3-dicarbonitrile (2). A mixture of compound 1 (0.58 g, 0.003 mol) and an equivalent amount of DDQ (0.68 g, 0.003 mol) was reuxed in the presence of absolute EtOH (20 mL)/pyridine for 6 h under N 2 gas.…”

“…20 Cytotoxicity (anticancer screening). There are two factors that can be relied upon to study the cytotoxicity activity of synthesized compounds towards any cell line: 21,22 (1) the formation of an intramolecular H-bond with any of one of the nucleotides in DNA; (2) the attraction force between the positive charge on the tested derivatives and the negative charge on the wall of the cell. The following SAR study was concluded by making a comparison between the Experimental results of the cytotoxicity of the tested compounds and their structures.…”

“… 1 There are many pharmaceutical and biological applications using phthalocyanines (Pcs) or metallo-phthalocyanines (M-Pcs). 2–4 There is great interest in phthalocyanines and metallo-phthalocyanines in the photodynamic therapy (PDT), wherein the first photosensitizers, namely, hematoporphyrin derivatives and Photofrin 5 were used. Cancer can be treated by the formation and accumulation of photosensitizers within tumor tissue after activation by light using photodynamic therapy.…”

Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

“…It is one of the five nucleobases and constitutes a promising structure in widespread natural products 34 . Uracil derivatives are interesting molecules in the area of drug discovery 35 since they exhibit significant pharmacological applications as antiviral 36 , anticancer, cytotoxic 37 , antimycobacterial 38 , anti-inflammatory 39 , antitumor 34,40 , and antibacterial 41 . Moreover, some uracil derivatives showed antithrombotic 42 , antidotal 43 and potent inhibitors of interleukin-8-induced neutrophil chemotaxis 44 .…”

In Memoriam – Brilliant Chemist, Professor Larisa Tomilova

“…[31][32][33][34] The new direction of recent research of Larisa Tomilova group was devoted to phthalocyanine-based catalysis, including synthesis of biologically-active compounds. [35][36][37][38][39][40] The main achievements of Professor L. Tomilova was summarized in recent book entitled «Advances in the synthesis and investigation of the properties of phthalocyanines and their analogues» published in Russian language in 2019. [41] Under supervision of Professor Larisa Godvigovna Tomilova more than 20 postgraduate students have obtained their Ph.D. degrees and 19 Master degrees.…”