Aminouracil and aminothiouracil as versatile precursors for a variety of heterocyclic systems

Abstract

Heterocycles, particularly pyrimidine derivatives, which are present in many natural products and many interesting synthetic compounds, are the most diverse class of organic compounds and have significant chemical, biomedical and industrial applications. Uracil, a pyrimidine derivative, constitutes a promising structure in widespread natural products and many of its derivatives exhibited significant pharmacological properties. They have been widely used as starting materials for the synthesis of a huge number of biologically important nitrogen-containing heterocycles. This review casts light on various methods for the construction of different heterocyclic systems utilizing aminouracil and aminothiouracil as versatile precursors. The heterocyclic systems mentioned in this review are categorized according to the type of the heterocyclic systems.

Synthesis, identification of some new tetrazoline, thiazolidin-4-one and imidazolidin-4-one derivatives and evaluation anticancer of their molecular docking and anti-oxidant experimental

“…A solution of 1,3-dimethyl-6-(amino aceto hydrazine) pyrimidine-2,4-dione-6-yl, para substituted aromatic aldehydes and absolute ethanol Its solvents were thoroughly combined with glacial acetic acid a catalytic three drops to synthesized Schiff bases derivatives (1-5) in table-1 showed the physical properties and FTIR of compound (1-5). The FTIR spectrum [34] showing in figure (1)(2)(3)(4)(5) 13 C-NMR spectrum data of this compound (5) and showing in Figure 22.…”

“…All of the produced compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) were either as active as the ordinary ascorbic acid or somewhat less active. The quantities of 50, 100, and 150 g /ml were used in a (2,2-diphenyl-1-picrylhydrazyl) test.…”

“…The phosphomolybdenum method was used to calculate the combined antioxidant power of all synthesized compounds (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). This technique relies on the ability of synthesized compounds to convert colorless 70 Molybdenum(VI) to colored Molybdenum(V) via the formation of a green phosphate -Mo(V) complex at acidic pH.…”

“…Uracil is an essential pyrimidine representative. It is one of the five nucleobases and a promising structure in many natural products [1]. Uracil derivatives are important intermediates in the purine synthesis.…”

Synthesis, Herbicidal Activity, Mode of Action, and In Silico Analysis of Novel Pyrido[2,3-d]pyrimidine Compounds

“…Heterocyclic molecules are important scaffolds for synthetic and natural derivatives because of their wide range of biological activities [1][2][3][4][5]. Uracils are a class of natural bioactive compounds that exist in humans, animals, plants and microorganisms and possess diverse biological activities [6][7][8][9][10]. Hence, uracils are important nitrogen-linked heterocyclic molecules, which have received extensive attention in the field of agricultural chemistry because of their outstanding insecticidal, fungicidal and herbicidal bioactivities [11][12][13][14][15].…”