The SYNTAX score does not predict presence of carotid disease in a multivessel coronary disease population

Costanzo, Luca; Campisano, Maria Barbara; Capodanno, Davide; Sole, Andrea; Grasso, Carmelo; Ragusa, Maria Alessandra; Ronsivalle, Giuseppe; Tamburino, C; Tamburino, Corrado; Pino, Luigi Di

doi:10.1002/ccd.25320

Cited by 12 publications

(16 citation statements)

References 32 publications

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“…In a recent study, the SYNTAX score has not been found to be associated with carotid atherosclerosis in patients with multivessel coronary disease. 15) In contrast, we demonstrated an association between the SYNTAX score and significant carotid stenosis. However, this association was not an independent finding.…”

Section: Discussioncontrasting

confidence: 63%

Association between the Gensini Score and Carotid Artery Stenosis

et al. 2016

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Background and ObjectivesThe aim of this study was to evaluate the association between the extent of coronary artery disease assessed by the Gensini score and/or the SYNTAX score and the significant carotid stenosis in patients undergoing coronary artery bypass grafting (CABG).Subjects and MethodsA total of 225 patients who had carotid doppler ultrasonography prior to CABG were included retrospectively. Significant coronary artery disease was assumed as a lumen diameter stenosis of ≥50% in any of the major epicardial coronary arteries. The severity of carotid stenosis was determined by B-mode and duplex ultrasonography. Clinically significant carotid stenosis was defined as peak systolic velocity greater than 125 cm/s.ResultsThe mean value of SYNTAX score and Gensini score was highest in patients allocated to significant carotid stenosis (22.98±7.32, p<0.001 and 77.40±32.35, p<0.001, respectively). The other risk factors for significant carotid stenosis were found to be male gender (p=0.029), carotid bruit (p<0.001), diabetes (p=0.021), left main disease (p=0.002), 3-vessel disease (p=0.008), chronic total coronary occlusion (p=0.001), and coronary artery calcification (p=0.001) in univariate analysis. However, only the Gensini score (odds ratio[OR]=1.030, p=0.004), carotid bruit (OR=0.068, p<0.001), and male gender (OR=0.190, p=0.003) were the independent predictors. The Gensini score cut off value predicting significant carotid stenosis was 50.5 with 77% sensitivity (p<0.001).ConclusionThe Gensini score may be used to identify patients at high risk for significant carotid stenosis prior to CABG.

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Section: Discussioncontrasting

confidence: 63%

Association between the Gensini Score and Carotid Artery Stenosis

et al. 2016

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“…As shown previously in another study from our group, we found no relation between the SxScore and carotid disease in a multivessel coronary artery disease population while age was found to be independently associated with the presence of CLs [8]. Therefore, other factors apart from the complexity of CAD are likely important to predict the presence of carotid disease.…”

Section: Discussionsupporting

confidence: 60%

“…Conversely, in a recent paper investigating the relationship between SxScore and features of carotid atherosclerosis in patients with multivessel CAD, we found that the SxScore did not predict the presence of carotid disease [8]. The SYNTAX Score II (SxScore II) has been developed by a combination of clinical and anatomical predictors [9] to improve individualized treatment decisions.…”

Section: Introductionmentioning

confidence: 94%

“…Intima-media thickness (IMT), presence of carotid lesion (CL), percentage of maximal stenosis and significant carotid disease (SCD) were defined as described previously [8]. Briefly, IMT was defined as the distance between the leading edge of the lumen-intima echo and the leading edge of the media-adventitia echo; CL was defined as the presence of focal wall thickening that is ≥50% greater than that of the surrounding vessel wall or as a focal region with IMT N 1.5 mm that protrudes into the lumen; SCD was defined as a lesion producing a ≥ 60% diameter stenosis, calculated using the North American Symptomatic Carotid Endarterectomy Trial (NASCET) method [12], with a peak systolic velocity (PSV) N 125 cm/s and a carotid ratio (internal carotid PSV/common carotid PSV) N 3.…”

Section: Carotid Ultrasound Evaluationmentioning

confidence: 99%

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SYNTAX Score II predicts carotid disease in a multivessel coronary disease population

Costanzo¹,

Capodanno²,

Manichino³

et al. 2015

International Journal of Cardiology

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“…By contrast, there are some contrary studies in the literature. Costanzo et al [ 4 ] have shown the high prevalence of carotid lesions in patients with complex CAD; whilst SS did not seem to correlate with carotid atherosclerosis, they established their work on 204 consecutive patients with established multi-vessel CAD and divided them into three groups according to SYNTAX: < 14, from 15 to 24, and ≥25; then, they found non-significant difference of the three groups in correlation with CIMT, p = 0.38 [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

A real-life correlation between clinical syntax score II and carotid intima-media thickness in patients with stable coronary artery disease

Abdelnabi

Tok

Öz

et al. 2020

Journal of the Saudi Heart Association

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Background SYNTAX score II (SSII) is an update of the established SYNTAX score (SS) that uses clinical variables such as age, sex, creatinine clearance, left ventricular ejection fraction, chronic obstructive pulmonary disease, and peripheral arterial disease. Furthermore, SSII has been proven to be a more powerful predictive tool than SS in patients with complex coronary artery disease (CAD). Carotid õntima-media thickness (CIMT) is a widely used noninvasive evidence for subclinical or early atherosclerosis, and it was proved to be an independent predictor for cardiovascular events. Most of the previously published articles studied the association between the CIMT with old cardiovascular scoring systems such as SSI and Gensini score with debatable data about their correlation. Aim To study the correlation between SSII and CIMT in stable CAD patients undergoing elective coronary angiography (CA). Method and patients A prospective study including 155 patients undergoing elective CA for stable CAD excluding patients with history of acute coronary syndrome, previous coronary revascularization either by percutaneous coronary intervention or coronary artery bypass grafting, and previous cerebrovascular stroke. Results The mean age of patients was 58.25 ± 16.46 years, and 79 patients (50.96%) were men. The mean SSII score was 10.23 ± 11.36 and mean CIMT was 0.85 ± 0.24. The correlation between SSII and CIMT using Spearman correlation showed a strong correlation between SSII score and CIMT with correlation coefficient r = 0.752. Conclusion The study showed a strong positive correlation between SSII and CIMT in stable CAD patients undergoing elective CA.

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The SYNTAX score does not predict presence of carotid disease in a multivessel coronary disease population

Abstract: We found high prevalence of CL in patients with multivessel complex CAD. However, SxScore does not seem to correlate with carotid atherosclerosis.

Cited by 12 publications

References 32 publications

Association between the Gensini Score and Carotid Artery Stenosis

Association between the Gensini Score and Carotid Artery Stenosis

SYNTAX Score II predicts carotid disease in a multivessel coronary disease population

A real-life correlation between clinical syntax score II and carotid intima-media thickness in patients with stable coronary artery disease

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