The synergistic effects of quercetin-containing 3D-printed mesoporous calcium silicate/calcium sulfate/poly-ε-caprolactone scaffolds for the promotion of osteogenesis in mesenchymal stem cells

Huang, Kuo-Hao; Chen, Cheng-Yu; Chang, Chun-Yao; Chen, Yiwen; Lin, Chang‐Ching

doi:10.1016/j.jfma.2021.01.024

Cited by 22 publications

(9 citation statements)

References 34 publications

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“…It has been demonstrated that quercetin positively interacts with bone cells, promoting osteoblast growth, and effectively slows or stops osteoclast activity. According to research, quercetin plays a key role in regulating the processes of bone tissue renewal and inflammation ( 6 ). Quercetin aids in treating diabetic osteopenia as it lowers blood glucose levels.…”

Section: Potential Health Applications Of Quercetinmentioning

confidence: 99%

“…Compared to quercetin, the conjugated form of quercetin glycoside has a high absorption rate ( 5 ). About 77 times more quercetin is found in onion peel than in the edible section ( 6 ). Numerous methods, including solvent extraction, ultrasound-assisted extraction, microwave-assisted extraction, and the combination of strong pulsed light and subcritical water extraction, can be used to extract bioactive components from onion skin ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

“…About 77 times more quercetin is found in onion peel than in the edible section ( 6 ). Numerous methods, including solvent extraction, ultrasound-assisted extraction, microwave-assisted extraction, and the combination of strong pulsed light and subcritical water extraction, can be used to extract bioactive components from onion skin ( 6 ). For the first time, quercetin 3-galactoside has been found in the vegetative parts of Azadirachta indica , also known as neem.…”

Section: Introductionmentioning

confidence: 99%

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Promising bioactive properties of quercetin for potential food applications and health benefits: A review

et al. 2022

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Naturally occurring phytochemicals with promising biological properties are quercetin and its derivatives. Quercetin has been thoroughly studied for its antidiabetic, antibacterial, anti-inflammatory, anti-Alzheimer's, anti-arthritic, antioxidant, cardiovascular, and wound-healing properties. Anticancer activity of quercetin against cancer cell lines has also recently been revealed. The majority of the Western diet contains quercetin and its derivatives, therefore consuming them as part of a meal or as a food supplement may be sufficient for people to take advantage of their preventive effects. Bioavailability-based drug-delivery systems of quercetin have been heavily studied. Fruits, seeds, vegetables, bracken fern, coffee, tea, and other plants all contain quercetin, as do natural colors. One naturally occurring antioxidant is quercetin, whose anticancer effects have been discussed in detail. It has several properties that could make it an effective anti-cancer agent. Numerous researches have shown that quercetin plays a substantial part in the suppression of cancer cells in the breast, colon, prostate, ovary, endometrial, and lung tumors. The current study includes a concise explanation of quercetin's action mechanism and potential health applications.

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Section: Potential Health Applications Of Quercetinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Promising bioactive properties of quercetin for potential food applications and health benefits: A review

et al. 2022

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“…In China, traditional Chinese medicine (TCM) has been widely used to treat various human diseases for years. More importantly, some specific active constituents in TCM have been shown to promote tissue regeneration as growth factors recently. , Clematis triterpenoid saponin (CTS) is the main component of Clematis chinensis Osbeck which has long been used in the treatment of KOA. , CTS displays a strong cartilage protective effect and can significantly inhibit inflammation, alleviate oxidative stress injury, and protect chondrocytes from apoptosis. − Remarkably, CTS can prevent chondrocyte degeneration by upregulating cell proliferation activity and cartilage matrix collagen secretion. , Therefore, we speculate that CTS may enhance cartilage regeneration and act as a bioactive factor in CTE scaffolds.…”

Section: Introductionmentioning

confidence: 97%

“…More importantly, some specific active constituents in TCM have been shown to promote tissue regeneration as growth factors recently. 30,31 Clematis triterpenoid saponin (CTS) is the main component of Clematis chinensis Osbeck which has long been used in the treatment of KOA. 32,33 CTS displays a strong cartilage protective effect and can significantly inhibit inflammation, alleviate oxidative stress injury, and protect chondrocytes from apoptosis.…”

Section: Introductionmentioning

confidence: 99%

Cartilage Repair Using Clematis Triterpenoid Saponin Delivery Microcarrier, Cultured in a Microgravity Bioreactor Prior to Application in Rabbit Model

Pan

et al. 2022

ACS Biomater. Sci. Eng.

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Cartilage tissue engineering provides a promising method for the repair of articular cartilage defects, requiring appropriate biological scaffolds and necessary growth factors to enhance the efficiency of cartilage regeneration. Here, a silk fibroin (SF) microcarrier and a clematis triterpenoid saponin delivery SF (CTS-SF) microcarrier were prepared by the high-voltage electrostatic differentiation and lyophilization method, and chondrocytes were carried under the simulated microgravity condition by a rotating cell culture system. SF and CTS-SF microspheres were relatively uniform in size and had a porous structure with good swelling and cytocompatibility. Further, CTS-SF microcarriers could sustainably release CTSs in the monitored 10 days. Compared with the monolayer culture, chondrocytes under the microgravity condition maintained a better chondrogenic phenotype and showed better proliferation ability after culture on microcarriers. Moreover, the sustained release of CTS from CTS-SF microcarriers upregulated transforming growth factor-β, Smad2, and Smad3 signals, contributing to promote chondrogenesis. Hence, the biophysical effects of microgravity and bioactivities of CTS-ST were used for chondrocyte expansion and phenotype maintenance in vitro. With prolonged expansion, SF- and CTS-SF-based microcarrier–cell composites were directly implanted in vivo to repair rabbit articular defects. Gross evaluations, histopathological examinations, and biochemical analysis indicated that SF- and CTS-SF-based composites exhibited cartilage-like tissue repair compared with the nontreated group. Further, CTS-SF-based composites displayed superior hyaline cartilage-like repair that integrated with the surrounding cartilage better and higher cartilage extracellular matrix content. In conclusion, these results provide an alternative preparation method for drug-delivered SF microcarrier and a culture method for maintaining the chondrogenic phenotype of seed cells based on the microgravity environment. CTS showed its bioactive function, and the application of CTS-SF microcarriers can help repair and regenerate cartilage defects.

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TP53-mediated miR-2861 promotes osteogenic differentiation of BMSCs by targeting Smad7

Zhou¹,

Li²,

Shu³

et al. 2021

Mol Cell Biochem

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The synergistic effects of quercetin-containing 3D-printed mesoporous calcium silicate/calcium sulfate/poly-ε-caprolactone scaffolds for the promotion of osteogenesis in mesenchymal stem cells

Cited by 22 publications

References 34 publications

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Promising bioactive properties of quercetin for potential food applications and health benefits: A review

Cartilage Repair Using Clematis Triterpenoid Saponin Delivery Microcarrier, Cultured in a Microgravity Bioreactor Prior to Application in Rabbit Model

TP53-mediated miR-2861 promotes osteogenic differentiation of BMSCs by targeting Smad7

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