The Synergistic Effects of Different Radiations

Zaider, Marco; Rossi, Harald H.

doi:10.2307/3575352

Cited by 152 publications

(102 citation statements)

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“…In these experiments, SLD from high-LET radiation is expressed through interaction with SLD induced by low-LET radiation; i.e., the combined irradiation is more effective in causing lethal damage than predicted for independent action (55). Early studies by Barendsen on sequential exposures of T-1 cells to at particles at 140 keV/pm followed by different doses of X rays did not reveal the presence of significant SLD from this high-LET radiation (4).…”

Section: Single-track Lethal Damage As a Function Of Letmentioning

confidence: 96%

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The Relationships between RBE and LET for Different Types of Lethal Damage in Mammalian Cells: Biophysical and Molecular Mechanisms

Barendsen¹

1994

Radiation Research

100

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The relative biological effectiveness (RBE) of radiations as a function of linear energy transfer (LET) is analyzed for different types of damage causing reproductive death of mammalian cells. Survival curves are evaluated assuming a linear-quadratic dose dependence of the induction of reproductive death of cells. The linear term represents damage from single particle tracks and the quadratic term represents damage due to interaction of lesions from independent tracks. Differences and similarities are discussed of the LET dependence of single-track lethal damage, sublethal damage, potentially lethal damage and DNA double-strand breaks. The RBE-LET relationships are correlated with local energy deposition in small regions of the cells. The analysis shows that single-track lethal damage is composed in part of a type of damage that is not repaired by delayed plating and is very strongly dependent on LET with maximum RBE values up to 20, while another component consists of potentially lethal damage that is weakly dependent on LET with maximum RBE values less than 3. Potentially lethal damage and sublethal damage depend similarly on LET as DNA double-strand breaks. The sector of single-track damage which is not repaired by delayed plating is hypothesized to be caused through a repair-exchange mechanism involving two double-strand breaks induced close together. The identification of these different components of damage leads to an interpretation of differences in radiosensitivity and in RBE-LET relationships among various types of cells.

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Section: Single-track Lethal Damage As a Function Of Letmentioning

confidence: 96%

“…The induction of SLD by high-LET radiations can be studied more accurately by analysis of the increase in effectiveness of low-LET radiation applied together with, or shortly after, initial doses of high-LET radiations (4,(52)(53)(54)(55).…”

Section: Single-track Lethal Damage As a Function Of Letmentioning

confidence: 99%

The Relationships between RBE and LET for Different Types of Lethal Damage in Mammalian Cells: Biophysical and Molecular Mechanisms

Barendsen¹

1994

Radiation Research

100

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“…(2) Survival curves published by Bird et al . (1980) for Chinese Mathematical equations for the analysis of data obtained for sequential irradiations of cells with high-and low-LET radiations were provided by Zaider and Rossi (1980) and in a more general treatment, by Zaider (1990) . The surviving fraction S(DH +DL)/S(0) after a dose D L of low-LET radiation added to a dose DH of high-LET radiation can be written as :…”

Section: Rbe-let Relationships For Sub-lethal Damagementioning

confidence: 99%

Sublethal Damage and DNA Double Strand Breaks Have Similar RBE-LET Relationships: Evidence and Implications

Barendsen

1993

International Journal of Radiation Biology

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“…7, and therefore potentially a different biologic effect. In accordance with the mechanistic model described earlier, it becomes possible for two-event damage to arise in which one event originates from each modality (15,16). The type B component of damage will be affected by the interaction of sublethal events from the two therapies, and the equation for BED will now feature intermodality terms in addition to the intramodality terms introduced here.…”

Section: The Lq Modelmentioning

confidence: 74%