The synergistic effect of traditional Chinese medicine prescription and rumen‐protected γ‐aminobutyric acid on beef cattle under heat stress

Abstract

Heat stress (HS), which is usually induced by both hot and humid weather, inhibits animal productivity (Bloemhof et al., 2013).When the animals are under HS, the growth rate is affected by various adverse factors, such as feed intake reduction, rumen environment disturbance and nutrient digestibility descent (Berman, 2005). Numerous studies have proposed that HS increases the animal breeding cost and economic losses to the livestock industry due to the decrease in feed intake and nutrient digestibility (Chand et al., 2014;Khan et al., 2011). HS is one of the most serious concerns facing cattle industry today with the modern development and expansion of beef cattle industry (Dash et al., 2016). In many areas, the great economic loss caused by this problem is seasonal, and the approach to relieving the damage induced by HS has become urgent issues for livestock production. Although the modern

Maternal Dietary Supplementation with γ-Aminobutyric Acid Alleviated Oxidative Stress in Gestating Sows and Their Offspring by Regulating GABRP

“…GABA mainly exerts effects by binding to GABRP, which played an important role during the process of embryo implantation and placenta formation [ 14 , 39 , 40 ]. Previous studies have confirmed that GABRP is widely distributed in various tissues of sows during late gestation [ 15 ], and GABRP expression was significantly increased during the embryo implantation in human and mice [ 39 , 40 ], which suggested that GABRP may be important for embryo development and mother–fetus communication. Our results found that oxidative stress significantly down-regulated the expression of the GABRP gene in pTr-2 cells, while GABA pretreatment can increase the expression of the GABRP gene, indicating that GABA may exert an anti-oxidative effect by combining with GABRP.…”

“…Gamma-aminobutyric acid (GABA) is a natural important functional nonessential amino acid that has several physiological functions, such as anti-inflammation, anti-apoptosis, and anti-oxidation [ 11 , 12 , 13 , 14 ]. Although GABA is an inhibitory neurotransmitter in the mammalian central nervous system, GABA signals also widely exist in peripheral tissues and organs, such as the ovaries, placenta, and uterus [ 15 , 16 , 17 ]. At the same time, early studies have shown that GABA can activate the GABA receptor π subunit (GABRP) to regulate the development of human chorionic trophoblast cells [ 18 , 19 ].…”

Effects of rumen-protective γ-aminobutyric acid additive on lactation performance and serum biochemistry in heat-stressed cows

“…Higher DMI and stable lactation in dairy cows require a better antioxidant status, which is reflected by changes in serum metabolites ( 12 , 34 ). SOD plays an important role in the animal’s antioxidant defense mechanism, while GSH-PX scavenges peroxides and hydroxyl radicals produced during cellular respiratory metabolism ( 19 , 35 ). T-AOC is the total antioxidant level of various antioxidants and antioxidant enzymes, representing the body’s ability to fight oxidation ( 12 , 34 ).…”

“…In addition to this, dietary supplementation with GABA improved nutrient digestibility, growth performance and antioxidant status in heat-stressed beef cows ( 18 ). Chen et al study showed that GABA in synergy with Chinese herbs could effectively modulate the heat stress response in beef cows by improving antioxidant capacity, serum parameters and heat shock protein (HSP) expression ( 19 ). Previous studies have shown GABA to be beneficial to heat-stressed cows in terms of feed intake, lactation performance and animal health.…”

About the possibilities of using phytobiotic additives in the diets of farm animals (review)

“…Рецепты традиционной китайской медицины (ТКМ) или ГАМК, защищённые от рубца (RP-GABA), могут эффективно облегчить тепловой стресс (HS) у крупного рогатого скота, но совместное влияние лекарственных растений и защита их от рубцового пищеварения на стресс у крупного рогатого скота полностью не выяснено. В результате проведённого исследования Jian Chen и соавторами было выявлено, ТКМ или ГАМК могут эффективно смягчать реакцию ГС у мясного скота за счет улучшения антиоксидантной способности, параметров сыворотки и экспрессии, в то время как их комбинация оказывает синергетический эффект на облегчение ГС (Chen J et al, 2021).…”