The syndrome of undifferentiated connective tissue dysplasia in a combination with hereditary thrombophilia as a cause of primary female in fertility

Kogan, E. A.; Nikolenko, V. N.; Zanozin, A. S.; Демура, Т. А.; Kolosovsky, D Yu

doi:10.14300/mnnc.2016.11067

Cited by 3 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, there has been an increase in the number of musculoskeletal disorders during physical training [1] and in the number of patients with characteristic morphological signs of connective tissue dysplasia (СTD) [2][3][4]. CTD manifestation is due to inherited mutations of genes encoding the synthesis and spatial organization of collagen, structural proteins and proteincarbohydrate complexes, enzymes and their co-factors [2][3][4][5][6]. At the same time, adverse environmental factors play an important role in clinical manifestation of this condition [7,8].…”

Section: Introductionmentioning

confidence: 99%

Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders

Николенко

Oganesyan

Vovkogon

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Connective tissue dysplasia (CTD) is a risk factor for musculoskeletal disorders. Changes caused by disorganization of collagen and elastin fibers lead to the inability of withstanding heavy mechanical stress. In clinical practice, diagnosis of these disorders depends on physical and anthropomorphic evaluation. Methods Forty-eight patients with frequent post-exercise musculoskeletal disorders were evaluated for CTD. The control group included 36 healthy participants. Both groups were evaluated via therapeutic examination with assessment of anthropometric indicators and physical-physiological evaluation, surveying and gathering of anamnesis. Based on testing results, study participants were evaluated on CTD presence and risk factors. Results All experimental group patients had connective tissue dysplasia of moderate and severe degree, with a total score of 49.44 ± 13.1. Certain morphological characteristics showed prevalence, allowing to determine pathognomonic predictors of high predisposition to frequent post-exercise musculoskeletal disorders. Back pain (100%), asthenic syndrome and kyphotic spinal deformation (75%), high gothic palate, hypermobility of joints and the auricles, excessive elasticity (63%), varicose veins of the lower extremities (56%) and hemorrhoids (56%), changes in the shape of the legs and temporomandibular joint (50%) showed to be significant clinical factors indicating possible connective tissue dysplasia. Conclusions The presence of these diagnostically significant morphological signs of CTD in humans is a pathognomonic predictor of a high predisposition to frequent injuries. Their early detection helps promote proper appointment of adequate physical activity regimen and develop treatment for the underlying cause.

show abstract

Section: Introductionmentioning

confidence: 99%

Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders

Николенко

Oganesyan

Vovkogon

et al. 2020

BMC Musculoskelet Disord

View full text Add to dashboard Cite

show abstract

Reproductive Health of Female Patients with Connective Tissue Dysplasia

Karachentsova,

Goryainova,

Sibirskaya

et al. 2023

Pediatr. farmakol.

View full text Add to dashboard Cite

Connective tissue dysplasia is congenital anomaly manifesting as different organ's and system's alterations: locomotor, skin, visceral dysfunctions. This article presents literature review covering such topical issues as female reproductive system features affected by mesenchymal pathology (undifferentiated forms of connective tissue dysplasia) and its medicamentous management (microelements, hormonal drugs, adaptogens). The analysis of original studies on this topic has revealed that connective tissue dysplasia has significant effect on female reproductive function development and can be complicated by various menstrual dysfunctions (hypomenorrhea syndrome, oligomenorrhea, opsomenorrhea, uterine bleedings, and secondary amenorrhea) as well as by endocrine changes (anti-Mullerian hormone deficiency, hypoprolactinaemia, hypoestrogenemia, etc.). Gestation and delivery features in patients with connective tissue dysplasia (preeclampsia, premature birth, and fetal abnormalities) were also revealed.

show abstract

The morphological and molecular biological signs of impaired endometrial receptivity in infertility in women suffering from external genital endometriosis

Парамонова¹,

Kogan²,

Kolotovkina³

et al. 2018

Arkh. patol.

View full text Add to dashboard Cite

It was established that in the infertile women with Stage I-II EGE and those with OEC, endometrial receptivity was impaired, which was manifested by a decline in the number of superficial epithelial cells containing mature pinopods, as well as a decrease in the endometrial level of the key receptivity markers: αvβ3 integrin, LIF, glycodelin A, and HOXA10 and increases in the synthesis of aromatase and in the imbalance of endometrial stromal expression of ER and PR detected by immunohistochemistry (IHC). Molecular genetic study showed lower mRNA expression levels of the HOXA-10, LIFR, and PgR genes, which confirms the data obtained by IHC.

show abstract

The syndrome of undifferentiated connective tissue dysplasia in a combination with hereditary thrombophilia as a cause of primary female in fertility

Cited by 3 publications

References 0 publications

Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders

Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders

Reproductive Health of Female Patients with Connective Tissue Dysplasia

The morphological and molecular biological signs of impaired endometrial receptivity in infertility in women suffering from external genital endometriosis

Contact Info

Product

Resources

About