Morphological signs of connective tissue dysplasia as predictors of frequent post-exercise musculoskeletal disorders

Abstract

Background Connective tissue dysplasia (CTD) is a risk factor for musculoskeletal disorders. Changes caused by disorganization of collagen and elastin fibers lead to the inability of withstanding heavy mechanical stress. In clinical practice, diagnosis of these disorders depends on physical and anthropomorphic evaluation. Methods Forty-eight patients with frequent post-exercise musculoskeletal disorders were evaluated for CTD. The control group included 36 healthy participants. Both groups were evaluated via therapeutic examination with assessment of anthropometric indicators and physical-physiological evaluation, surveying and gathering of anamnesis. Based on testing results, study participants were evaluated on CTD presence and risk factors. Results All experimental group patients had connective tissue dysplasia of moderate and severe degree, with a total score of 49.44 ± 13.1. Certain morphological characteristics showed prevalence, allowing to determine pathognomonic predictors of high predisposition to frequent post-exercise musculoskeletal disorders. Back pain (100%), asthenic syndrome and kyphotic spinal deformation (75%), high gothic palate, hypermobility of joints and the auricles, excessive elasticity (63%), varicose veins of the lower extremities (56%) and hemorrhoids (56%), changes in the shape of the legs and temporomandibular joint (50%) showed to be significant clinical factors indicating possible connective tissue dysplasia. Conclusions The presence of these diagnostically significant morphological signs of CTD in humans is a pathognomonic predictor of a high predisposition to frequent injuries. Their early detection helps promote proper appointment of adequate physical activity regimen and develop treatment for the underlying cause.

Age Pathognomonic Indicators of Injury Predisposition as a Basis for Public Health Preservation during Physical Activity

“…Clinical-instrumental examination was aimed at identifying morphometric signs of connective tissue pathology according to a questionnaire compiled at the First Moscow State Medical University [ 4 ]. Body proportionality was assessed according to Verveka and Pignet indices, body weight was assessed via the Quetelet and Vargi indices, dolichostenomelia was assessed with the arm length/height, upper body/lower body, foot length/height, and wrist length/height ratios.…”

“…Frequent post-exercise injury is often associated with connective tissue disorders [ 4 ]. This pathology is diagnosed by identifying a complex of significant morphometric signs of connective tissue pathology [ 2 ].…”

Phenotypic manifestations of connective tissue dysplasia in individuals with joint hypermobility

“…Также обнаружена тесная взаимосвязь чувствительных волокон блуждаю щего нерва и TNX -при недостаточности тенасцина снижается порог чувствительности афферентных окончаний блуждаю щего нерва, что приводит к более активной импульсации и релаксации нижнего пищеводного сфинктера [29]. Долихостеномелия -разновидность поражения костной системы при нДСТ, при которой происходит удлинение конечностей [30]. Механизм возникновения долихостеномелии малоизучен и требует дальнейшего исследования.…”

sCLC: a Clustering Linear Combination (CLC) Method for Multiple Phenotype Association Studies Based on GWAS Summary Statistics

“…Connective tissue dysplasia (CTD) and musculoskeletal disorders [27][28][29] , such as Systemic Lupus Erythematosus (SLE), Sjögren Syndrome (SS), and Rheumatoid Arthritis (RA), may influence the physical activity or movement of patients. These kinds of diseases seriously affect the quality of life of people and have been reported to be potentially affected by genetic factors 30 .…”