The syndrome of inappropriate secretion of antidiuretic hormone

Bartter, Frederic C.; Schwartz, William B.

doi:10.1016/0002-9343(67)90096-4

Cited by 1,172 publications

(416 citation statements)

References 106 publications

Supporting

Mentioning

385

Contrasting

Unclassified

Order By: Relevance

“…Syndrome of inappropriate anti diuretic hormone secretion (SIADH) is the commonest cause of chronic hyponatremia and in most of the cases the etiology remains unclear even after routine investigations [4]. Diagnostic criteria for SIADH include hypotonic hyponatremia, urine osmolality [100 mOsm/kg, in absence of evidence of extracellular volume depletion and with a normal thyroid, adrenal, cardiac, hepatic and renal function [5].…”

Section: Introductionmentioning

confidence: 99%

Urinary Retention as a Cause of Hyponatremia in an Elderly Man

Mahajan

Simon

2013

Ind J Clin Biochem

View full text Add to dashboard Cite

Hyponatremia is a common disorder in elderly and can result in changes in cognition, seizures, coma or even respiratory arrest if not recognised and treated. Syndrome of inappropriate anti diuretic hormone secretion (SIADH) is the most common cause of hyponatremia in elderly hospitalised patients and in most cases the etiology cannot be determined on routine investigations. We present a 76 year old male with symptomatic hyponatremia who had chronic urinary retention due to a urethral stricture. His sodium levels improved with catheterisation and worsened again after the catheter was removed. This supports the hypothesis that urinary retention and bladder distension can stimulate ADH release from the posterior pituitary, producing a picture similar to SIADH.

show abstract

Section: Introductionmentioning

confidence: 99%

Urinary Retention as a Cause of Hyponatremia in an Elderly Man

Mahajan

Simon

2013

Ind J Clin Biochem

View full text Add to dashboard Cite

show abstract

“…Of the various types of human lung cancer, SCCL, 3 also called "oat-cell" carcinoma, is one of the most aggressive. In the United States, SCCL accounts for 20% of all primary lung carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin receptor pattern of expression in primary lung cancer and in normal human lung

et al. 2005

View full text Add to dashboard Cite

show abstract

“…HN is usually associated with a disturbance in vasopressin [antidiuretic hormone (ADH)], which can be synthesised independently of serum osmolality or circulating fluid volume under specific pathological or pharmacological conditions 1. Clinical criteria for the syndrome of inappropriate antidiuretic hormone secretion (SIADH) were established by Bartter and Schwartz 2 and have remained largely unchanged ever since 1. SIADH accounts for one‐third of all cases of HN 3.…”

Section: Introductionmentioning

confidence: 99%

Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH : a systematic review

2015

View full text Add to dashboard Cite

SummaryAimsHyponatraemia (HN) is the most common electrolyte balance disorder in clinical practice. Since the 1970s, demeclocycline has been used in some countries to treat chronic HN secondary to syndrome of inappropriate antidiuretic hormone secretion (SIADH). The precise mechanism of action of demeclocycline is unclear, but has been linked to the induction of nephrogenic diabetes insipidus. Furthermore, the safety profile of demeclocycline is variable with an inconsistent time to onset, and a potential for complications. There has been no systematic evaluation of the use of demeclocycline for the treatment of HN secondary to SIADH to date. A systematic literature review was performed to obtain an insight into the clinical safety and efficacy of demeclocycline for this condition.MethodsEmbase™, MEDLINE ®, MEDLINE ® In‐Process, and The Cochrane Library were searched on two occasions using MeSH terms combined with free‐text terms. References were screened by two independent reviewers. Relevant publications were then extracted by two independent reviewers, with a third reviewer collating and finalising extractions.ResultsThe searches returned a total of 705 hits. 632 abstracts were screened after the removal of duplicates. Following screening, 35 full‐length publications were reviewed. Of these, 17 were excluded, resulting in 18 studies deemed relevant for data extraction. Two were randomised controlled trials (RCTs), 16 were non‐RCTs, and 10 were case reports.DiscussionAlthough most reports suggest that demeclocycline can address serum sodium levels in specific patients with HN, efficacy is variable, and may depend upon the underlying aetiology. Demeclocycline dose adjustments can be complex, and as its use in clinical practice is not well defined, it can differ between healthcare professionals.ConclusionThere is a lack of clinical and economic evidence supporting the use of demeclocycline for HN secondary to SIADH. Patients receiving demeclocycline for HN secondary to SIADH must be closely monitored.

show abstract

The syndrome of inappropriate secretion of antidiuretic hormone

Cited by 1,172 publications

References 106 publications

Urinary Retention as a Cause of Hyponatremia in an Elderly Man

Urinary Retention as a Cause of Hyponatremia in an Elderly Man

Oxytocin receptor pattern of expression in primary lung cancer and in normal human lung

Evidence for the use of demeclocycline in the treatment of hyponatraemia secondary to SIADH : a systematic review

Contact Info

Product

Resources

About