The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation

Juárez‐Fernández, María; Porras, David Gimeno Ruiz de; Petrov, Petar; Román-Sagüillo, Sara; García‐Mediavilla, María Victoria; Soluyanova, Polina; Martínez‐Flórez, Susana; González‐Gallego, Javier; Nistal, Esther; Jover, Ramiro; Sánchez-Campos, Sonia

doi:10.3390/antiox10122001

Cited by 65 publications

(57 citation statements)

References 77 publications

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“…54 In addition, the CA/(glychocholic acid (GCA) + taurocholic acid (TCA) ratio was positively correlated with A. muciniphila, which may be related to BSHs. 54 Lactis 420™ (B420) was administered alone and in combination with prebiotics. The results showed changes in microbial and plasma BAs.…”

Section: Bile Acidsmentioning

confidence: 98%

“…After feeding A. muciniphila and quercetin, total plasma BAs increased, and secondary BAs increased overall, especially ωMCA and UDCA. The combination therapy reduced the levels of fasting blood glucose and plasma insulin and prevented obesity and inflammation 54 . In addition, the CA/(glychocholic acid (GCA) + taurocholic acid (TCA) ratio was positively correlated with A. muciniphila , which may be related to BSHs 54 .…”

Section: Beneficial Metabolites Of Gut Microbiotamentioning

confidence: 99%

“…The combination therapy reduced the levels of fasting blood glucose and plasma insulin and prevented obesity and inflammation 54 . In addition, the CA/(glychocholic acid (GCA) + taurocholic acid (TCA) ratio was positively correlated with A. muciniphila , which may be related to BSHs 54 . Lactis 420™ (B420) was administered alone and in combination with prebiotics.…”

Section: Beneficial Metabolites Of Gut Microbiotamentioning

confidence: 99%

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Gut and obesity/metabolic disease: Focus on microbiota metabolites

Lin

Zhu

2022

MedComm

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Obesity is often associated with the risk of chronic inflammation and other metabolic diseases, such as diabetes, cardiovascular disease, and cancer. The composition and activity of the gut microbiota play an important role in this process, affecting a range of physiological processes, such as nutrient absorption and energy metabolism. The active gut microbiota can produce a large number of physiologically active substances during the process of intestinal metabolism and reproduction, including short‐chain/long‐chain fatty acids, secondary bile acids, and tryptophan metabolites with beneficial effects on metabolism, as well as negative metabolites, including trimethylamine N‐oxide, delta‐valerobetaine, and imidazole propionate. How gut microbiota specifically affect and participate in metabolic and immune activities, especially the metabolites directly produced by gut microbiota, has attracted extensive attention. So far, some animal and human studies have shown that gut microbiota metabolites are correlated with host obesity, energy metabolism, and inflammation. Some pathways and mechanisms are slowly being discovered. Here, we will focus on the important metabolites of gut microbiota (beneficial and negative), and review their roles and mechanisms in obesity and related metabolic diseases, hoping to provide a new perspective for the treatment and remission of obesity and other metabolic diseases from the perspective of metabolites.

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Section: Bile Acidsmentioning

confidence: 98%

Section: Beneficial Metabolites Of Gut Microbiotamentioning

confidence: 99%

Section: Beneficial Metabolites Of Gut Microbiotamentioning

confidence: 99%

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Gut and obesity/metabolic disease: Focus on microbiota metabolites

Lin

Zhu

2022

MedComm

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“…Two double-blind, placebo-controlled clinical trials report that the mixture of Bifidobacterium bifidum BB-02 , Bifidobacterium lactis BL-01 , and inulin, as well as mixture of Lactobacillus acidophilus NCFM and lactitol can increase the growth of Bifidobacteria and Lactobacilli [ 213 , 215 ]; in addition, another clinical trial shows that the combination of Bifidobacterium longum and inulin increased the number of Actinobacteria and Firmicutes , and decreased Proteobacteria [ 214 ]. Interestingly, Marìa Juàrez-Fernàndez et al observed the beneficial effect of the symbiotic combination of the NGP A. muciniphila and quercetin on NAFLD, by modulating GM composition and bile acid metabolism [ 216 ].…”

Section: Other Therapeutic Optionsmentioning

confidence: 99%

Age-Related NAFLD: The Use of Probiotics as a Supportive Therapeutic Intervention

Campagnoli

Marchesi

Vairetti

et al. 2022

Cells

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Human aging, a natural process characterized by structural and physiological changes, leads to alterations of homeostatic mechanisms, decline of biological functions, and subsequently, the organism becomes vulnerable to external stress or damage. In fact, the elderly population is prone to develop diseases due to deterioration of physiological and biological systems. With aging, the production of reactive oxygen species (ROS) increases, and this causes lipid, protein, and DNA damage, leading to cellular dysfunction and altered cellular processes. Indeed, oxidative stress plays a key role in the pathogenesis of several chronic disorders, including hepatic diseases, such as non-alcoholic fatty liver disease (NAFLD). NAFLD, the most common liver disorder in the Western world, is characterized by intrahepatic lipid accumulation; is highly prevalent in the aging population; and is closely associated with obesity, insulin resistance, hypertension, and dyslipidemia. Among the risk factors involved in the pathogenesis of NAFLD, the dysbiotic gut microbiota plays an essential role, leading to low-grade chronic inflammation, oxidative stress, and production of various toxic metabolites. The intestinal microbiota is a dynamic ecosystem of microbes involved in the maintenance of physiological homeostasis; the alteration of its composition and function, during aging, is implicated in different liver diseases. Therefore, gut microbiota restoration might be a complementary approach for treating NAFLD. The administration of probiotics, which can relieve oxidative stress and elicit several anti-aging properties, could be a strategy to modify the composition and restore a healthy gut microbiota. Indeed, probiotics could represent a valid supplement to prevent and/or help treating some diseases, such as NAFLD, thus improving the already available pharmacological intervention. Moreover, in aging, intervention of prebiotics and fecal microbiota transplantation, as well as probiotics, will provide novel therapeutic approaches. However, the relevant research is limited, and several scientific research works need to be done in the near future to confirm their efficacy.

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“…Obesity-attributable illnesses, such as cardiovascular disease have contributed to more than two-thirds of deaths globally, according to data from the Global Burden of Disease study ( 2 ). One of the underlying mechanisms contributing to obesity-related diseases is the development of systemic low-grade inflammation derived from adipose tissue ( 3 , 4 ). While chronic inflammation is often associated with increased oxidative stress ( 5 ), the literature has previously reported the role of oxidative stress in the pathogenesis of obesity-related diseases ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status

et al. 2022

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Childhood obesity is identified as one of the major public health issues to increase the risk for cardiometabolic diseases and related complications in adulthood. The literature has supported inflammation and oxidative stress as the primary underlying mechanisms involved in the pathogenesis of obesity-related diseases. Epidemiological evidence consistently shows the benefits of physical activity in the improvement of obesity-mediated inflammation and oxidative stress status. In this narrative mini-review, the available scientific evidence on the potential effects of exercise in alleviating these susceptibilities in childhood obesity will be assessed.

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The Synbiotic Combination of Akkermansia muciniphila and Quercetin Ameliorates Early Obesity and NAFLD through Gut Microbiota Reshaping and Bile Acid Metabolism Modulation

Cited by 65 publications

References 77 publications

Gut and obesity/metabolic disease: Focus on microbiota metabolites

Gut and obesity/metabolic disease: Focus on microbiota metabolites

Age-Related NAFLD: The Use of Probiotics as a Supportive Therapeutic Intervention

Exercise Outcomes in Childhood Obesity-Related Inflammation and Oxidative Status

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