The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract of<i>Liriope platyphylla</i>

Kim, Ji Eun; Lee, Yoen Kyung; Nam, So Hee; Choi, Sun; Goo, Jun Seo; Jang, Min Ju; Lee, Hee Seob; Son, Hyojoo; Lee, Chung Yeol; Hwang, Dae Youn

doi:10.5625/lar.2010.26.4.377

Cited by 22 publications

(18 citation statements)

References 21 publications

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“…On the other hand, the number of infiltrated mast cells decreased in the PA+FSC-treated group. This result was very similar to a previous study that investigated the therapeutic effects of Liriope platyphylla in a PA-induced AD mouse model [44,45]. Therfore, mast cells are an important marker to detect the effects of various components on AD therapy.…”

Section: Discussionsupporting

confidence: 91%

Therapeutic effects of fermented soycrud on phenotypes of atopic dermatitis induced by phthalic anhydride

et al. 2013

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Atopic dermatitis (AD), which is known as the most common pruritic skin disease, is caused by epidermal barrier dysfunction, allergies, microwave radiation, histamine intolerance, and genetic defects. To investigate the therapeutic effects of fermented soycrud (FSC) on AD pathology, alteration of AD phenotypes induced by phthalic anhydride (PA) treatment was assessed by ear thickness analysis, measurement of immune-related organ weights, ELISA, and histological and pathological analyses of ICR mice after FSC treatment for 2 weeks. Except for water content, the concentrations of most major components were lower in FSC compared to common tofu (CMT). Thymus and lymph node weights were significantly reduced in ICR mice treated with PA+CMT or PA+FSC, whereas spleen and body weights were maintained. Elevation of ear thickness induced by PA treatment was rapidly diminished in the CMT- and FSC-treated groups, although there was no significant difference between the two groups. Furthermore, significant reduction of epidermal thickness was detected in both the PA+CMT- and PA+FSC-treated groups. However, IgE concentration and dermal thickness were reduced only by PA+FSC treatment, whereas PA+CMT treatment maintained levels comparable to PA+vehicle treatment. The number of infiltrated mast cells was higher in the PA+vehicle-treated group compared to the untreated control. Following CMT or FSC treatment, mast cell infiltration was slightly reduced, although the CMT-treated group showed greater cell numbers. These results indicate that FSC may significantly relieve the phenotypes of AD induced by PA treatment and should be considered as a potential candidate for AD therapy.

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Section: Discussionsupporting

confidence: 91%

Therapeutic effects of fermented soycrud on phenotypes of atopic dermatitis induced by phthalic anhydride

et al. 2013

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“…In addition, a solution of RLP extracts was concentrated to dry pellets in a rotary evaporator (EYELA, Tokyo, Japan) and stored at -80℃ until needed. Analyses for the general compounds in LP and RLP were performed as previously described [11,16]. …”

Section: Methodsmentioning

confidence: 99%

“…Also, the differentiation of naive PC12 cells as well as improvement of learning and memory in mice were induced LP through upregulation of NGF secretion [7-10]. Furthermore, it relieved symptoms of atopic dermatitis in NC/Nga mice after phthalic anhydride (PA) treatment [11]. …”

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confidence: 99%

Toxicity of redLiriope platyphyllamanufactured by steaming process on liver and kidney organs of ICR mice

et al. 2012

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Red Liriope platyphylla (RLP) produced by steaming process has been reported to enhance the secretion of insulin and nerve growth factor (NGF). However, there has been no report on the toxicity of RLP in the specific organs of mice. To investigate the toxic effect of RLP, we tried to observe a significant alteration on body weight, food/water intake, organ weight, liver pathology and kidney pathology in female ICR mice received 12.5, 25.0 and 50.0 mg/kg body weight/day of RLP via gavage for 10 days. Out of seven organs including brain, heart, lung, liver, kidney, spleen and ovary, two organs (heart and lung) showed significantly decreased weights in the medium dosage RLP-treated group, whereas weights of other organs were maintained at constant levels in all dosage groups. In the liver toxicity analysis, no significant increase of alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate amino-transferase (AST) were detected in any RLP-treated group compared to vehicle-treated group. The specific pathological changes induced by most of toxic compounds were not observed in the liver in microscopic examination. Furthermore, in the kidney toxicological analysis, a significant enhancement of the blood urea nitrogen (BUN) concentration was detected in the high dosage RLP-treated group compared to the vehicle-treated group. However, the serum creatinine (CA) concentration on the serum biochemistry as well as the pathological changes in microscopic examination were not significantly different between the vehicle- and RLP-treated groups. Therefore, these results suggest that RLP does not induce any specific toxicity in liver or kidney tissues of mice, although the BUN level slightly increased in 50.0 mg/kg of RLP-treated group.

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“…L. platyphylla has long been used in traditional oriental herbal medicine for the treatment of asthma, bronchial and lung inflammation, obesity, diabetes, neuro degenerative diseases, and atopic dermatitis [2-7]. Of these therapeutic effects, the potential of L. platyphylla for treating obesity and diabetes has been intensively researched.…”

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confidence: 99%

RedLiriope platyphyllastimulated the insulin secretion through the regulation of calcium concentration in rat insulinoma cells and animal models

et al. 2013

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The aim of this study was to investigate the effects of Red L. platyphylla (RLP) on calcium and glucose levels during insulin secretion. To achieve this, alteration of insulin and calcium concentrations was measured in rat insulinoma-1 (INS-1) cells and animal models in response to RLP treatment. In INS-1 cells, maximum secretion of insulin was detected upon treatment with 200 µg/mL of RLP for 20 min. Nifedipine, an L-type calcium channel blocker, effectively inhibited insulin secretion from INS-1 cells. Regarding calcium levels, the maximum concentration of intracellular calcium in INS-1 cells was obtained by treatment with 100 µg/mL of RLP, whereas this level was reduced under conditions of 200 µg/mL of RLP. Further, RLP-treated INS-1 cells showed a higher level of intracellular calcium than that of L. platyphylla (LP), Korea White Ginseng (KWG), or Korea Red Ginseng (KRG)-treated cells. This RLP-induced increase in intracellular calcium was abrogated but not completely abolished upon treatment with 40 µM nifedipine in a dose-dependent manner. Furthermore, the insulin level was dramatically elevated upon co-treatment with high concentrations of glucose and RLP, whereas it was maintained at a low level in response to glucose and RLP co-treatment at low concentrations. In an animal experiment, the serum concentration of calcium increased or decreased upon RLP treatment according to glucose level compared to vehicle treatment. Therefore, these results suggest that insulin secretion induced by RLP treatment may be tightly correlated with calcium regulation, which suggests RLP is an excellent candidate for diabetes treatment.

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The Symptoms of Atopic Dermatitis in NC/Nga Mice Were Significantly Relieved by the Water Extract ofLiriope platyphylla

Cited by 22 publications

References 21 publications

Therapeutic effects of fermented soycrud on phenotypes of atopic dermatitis induced by phthalic anhydride

Therapeutic effects of fermented soycrud on phenotypes of atopic dermatitis induced by phthalic anhydride

Toxicity of redLiriope platyphyllamanufactured by steaming process on liver and kidney organs of ICR mice

RedLiriope platyphyllastimulated the insulin secretion through the regulation of calcium concentration in rat insulinoma cells and animal models

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