The sympathetic nervous system in acute kidney injury

Grisk, Olaf

doi:10.1111/apha.13404

Cited by 21 publications

(22 citation statements)

References 75 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, disturbances of the reflex autonomic control of heart rate have been associated with a doubling of the likelihood of new AF occurrence in patients with AMI [24]. In this regard, sympathetic over-activity has been demonstrated to occur in both CKD and acute kidney injury, and to be directly associated with the severity of renal failure [25,26]. Recently, inflammation, which is a typical feature of renal insufficiency, has also been shown to be independently associated with AF onset in AMI patients [27].…”

Section: Discussionmentioning

confidence: 99%

Impact of Glomerular Filtration Rate on the Incidence and Prognosis of New-Onset Atrial Fibrillation in Acute Myocardial Infarction

Cosentino

Ballarotto

Campodonico

et al. 2020

JCM

View full text Add to dashboard Cite

Background: Atrial fibrillation (AF) is a frequent complication of acute myocardial infarction (AMI) and is associated with a worse prognosis. Patients with chronic kidney disease are more likely to develop AF. Whether the association between AF and glomerular filtration rate (GFR) is also true in AMI has never been investigated. Methods: We prospectively enrolled 2445 AMI patients. New-onset AF was recorded during hospitalization. Estimated GFR was estimated at admission, and patients were grouped according to their GFR (group 1 (n = 1887): GFR >60; group 2 (n = 492): GFR 60–30; group 3 (n = 66): GFR <30 mL/min/1.73 m2). The primary endpoint was AF incidence. In-hospital and long-term (median 5 years) mortality were secondary endpoints. Results: The AF incidence in the population was 10%, and it was 8%, 16%, 24% in groups 1, 2, 3, respectively (p < 0.0001). In the overall population, AF was associated with a higher in-hospital (5% vs. 1%; p < 0.0001) and long-term (34% vs. 13%; p < 0.0001) mortality. In each study group, in-hospital mortality was higher in AF patients (3.5% vs. 0.5%, 6.5% vs. 3.0%, 19% vs. 8%, respectively; p < 0.0001). A similar trend was observed for long-term mortality in three groups (20% vs. 9%, 51% vs. 24%, 81% vs. 50%; p < 0.0001). The higher risk of in-hospital and long-term mortality associated with AF in each group was confirmed after adjustment for major confounders. Conclusions: This study demonstrates that new-onset AF incidence during AMI, as well as the associated in-hospital and long-term mortality, increases in parallel with GFR reduction assessed at admission.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of Glomerular Filtration Rate on the Incidence and Prognosis of New-Onset Atrial Fibrillation in Acute Myocardial Infarction

Cosentino

Ballarotto

Campodonico

et al. 2020

JCM

View full text Add to dashboard Cite

show abstract

“…It also aggravates ischemia/reperfusion‐induced renal damage through pro‐inflammatory mechanisms (reviewed in Ref. [17]).…”

Section: All Comorbidities Associated With Increased Morbidity/mortalmentioning

confidence: 99%

Sympathetic activation: a potential link between comorbidities and COVID‐19

et al. 2020

View full text Add to dashboard Cite

In coronavirus disease 2019 (COVID‐19), higher morbidity and mortality are associated with age, male gender, and comorbidities, such as chronic lung diseases, cardiovascular pathologies, hypertension, kidney diseases, diabetes mellitus, and obesity. All of the above conditions are characterized by increased sympathetic discharge, which may exert significant detrimental effects on COVID‐19 patients, through actions on the lungs, heart, blood vessels, kidneys, metabolism, and/or immune system. Furthermore, COVID‐19 may also increase sympathetic discharge, through changes in blood gases (chronic intermittent hypoxia, hyperpnea), angiotensin‐converting enzyme (ACE)1/ACE2 imbalance, immune/inflammatory factors, or emotional distress. Nevertheless, the potential role of the sympathetic nervous system has not yet been considered in the pathophysiology of COVID‐19. In our opinion, sympathetic overactivation could represent a so‐far undervalued mechanism for a vicious circle between COVID‐19 and comorbidities.

show abstract

“…For example, a change in this balance to a hypernoradrenergic state turns the ovary into a polycystic ovary, while a change to a cholinergic predominance is the healthy condition (Riquelme et al 2019). The concept that seems new for a typically endocrine organ is commonly found in all organs receiving autonomic control such as heart or the renal system (Velasquez et al 2019, Grisk 2020. Independent of the impact on ovarian function, this strengthens the concept that endocrine pathologies can be managed by modifying the autonomic tone to the organ (Lansdown & Rees 2012).…”

Section: Journal Of Endocrinologymentioning

confidence: 77%

“…Recently, neural regulation was developed as a new therapeutic tool to treat different pathologies (Birmingham et al 2014, Chavan & Tracey 2017, Pavlov & Tracey 2017, Velasquez et al 2019, Grisk 2020. The ovary is one of the organs in which sympathetic activity has been studied (Lara et al 2002, Lansdown & Rees 2012.…”

Section: Journal Of Endocrinologymentioning

confidence: 99%

In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats

Campo

Lagos

Lara

2020

Journal of Endocrinology

View full text Add to dashboard Cite

A high sympathetic tone is observed in the development and maintenance of the polycystic ovary (PCO) phenotype in rats. Neosaxitoxin (NeoSTX) specifically blocks neuronal voltage-dependent Na+ channels, and we studied the capacity of NeoSTX administered into the ovary to block sympathetic nerves and PCO phenotype that is induced by estradiol valerate (EV). The toxin was administered with a minipump inserted into the bursal cavity using two protocols: (1) the same day as EV administration and (2) 30 days after EV to block the final step of cyst development and maintenance of the condition. We studied the estrous cycling activity, follicular morphology, steroid plasma levels, and norepinephrine concentration. NeoSTX administered together with EV decreased NA intraovarian levels that were induced by EV, increased the number of corpora lutea, decreased the number of follicular cyst found after EV administration, and decreased the previously increased testosterone plasma levels induced by the PCO phenotype. Estrous cycling activity also recovered. NeoSTX applied after 30 days of EV administration showed near recovery of ovary function, suggesting that there is a specific window in which follicular development could be protected from cystic development. In addition, plasma testosterone levels decreased while those of progesterone increased. Our data strongly suggest that chronic inhibition of sympathetic nerves by a locally applied long-lasting toxin is a new tool to manage the polycystic phenotype in the rat and could be applied to other mammals depending on sympathetic nerve activity.

show abstract

The sympathetic nervous system in acute kidney injury

Cited by 21 publications

References 75 publications

Impact of Glomerular Filtration Rate on the Incidence and Prognosis of New-Onset Atrial Fibrillation in Acute Myocardial Infarction

Impact of Glomerular Filtration Rate on the Incidence and Prognosis of New-Onset Atrial Fibrillation in Acute Myocardial Infarction

Sympathetic activation: a potential link between comorbidities and COVID‐19

In vivo blockade of ovarian sympathetic activity by Neosaxitoxin prevents polycystic ovary in rats

Contact Info

Product

Resources

About