The sustaining effect of three polymers on the release of chlorhexidine from a controlled release drug device for root canal disinfection

Chlorhexidine delivery system from titanium/polybenzyl acrylate coating: Evaluation of cytotoxicity and early bacterial adhesion

“…11 Moreover, it is retained by the dentine hard tissues and is an effective irrigator to prevent root canal reinfection due to coronal leakage. 11,12 Nevertheless, several studies demonstrated that this compound may induce adverse effects.…”

“…11 Moreover, it is retained by the dentine hard tissues and is an effective irrigator to prevent root canal reinfection due to coronal leakage. 11,12 Nevertheless, several studies demonstrated that this compound may induce adverse effects. 14 Giannelli et al 15 suggested that direct application of CHX during regenerative therapy for the treatment of peri-implant diseases could exert serious toxic effects on gingival fibroblast, endothelial cells, and especially on alveolar osteoblasts, thus negatively interfering the early healing phase of these oral infections.…”

“…10 CHX is also effective against a wide variety of Gram-positive and Gram-negative organisms as well as fungi. 11 Additionally, it is retained by the dentine hard tissues and is an effective irrigator to prevent root canal reinfection due to coronal leakage. 12 CHX does not negatively affect the push-out bond strength in post bond cementation.…”

“…Further studies are needed to evaluate the release rate, antimicrobial effects, and the cytotoxicity of controlled drug release devices. 11,18 During the last decades, polymeric materials have significantly contributed to the development and improvement of implant and related devices [21][22][23] as well as drug delivery systems. [24][25][26] Amongst them, metha/acrylic polymers exhibit good adhesion to metal surfaces 27 and resistance to enzymatic hydrolysis, and may be good candidates for osseointegrated interfaces.…”

Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

“…A drug delivery system (DDS) can be used to regulate drug release or absorption rates or to deliver drugs to specific target sites, which ultimately ensures the effective presence of certain drugs over required treatment periods. Since the late 1940s, when the concept of the DDS was first applied within the fields of medicine and pharmacy 10,11) , DDSs have been applied in various dental areas such as dental implants, endodontics, and periodontal treatments for preventing infectious diseases 8,[12][13][14][15] . Bis-biguanide chlorhexidine (CHX) is an antimicrobial agent with broad-spectrum antimicrobial activity that is known to be effective at inhibiting Grampositive and Gram-negative, aerobic and anaerobic microorganisms, yeast, and fungi 16) .…”