Improving the efficacy of chlorhexidine-releasing elastomerics using a layer-by-layer coating technique

Abstract

The aims of this study were to identify the optimal concentration of coated orthodontic elastomerics using a layer-by-layer technique that can release chlorhexidine (CHX) as an antimicrobial material, and to measure the physical properties and antimicrobial effects of the coated elastomerics. Ethyl cellulose (EC) was used as the polymer, and five study groups with various combinations of solvents (i.e., ethanol and dichloromethane [DCM]) were included. The coated elastomerics were evaluated with a spectrophotometer to confirm the release of CHX, and their surfaces were observed by SEM. The CHX+EC+DCM group sustained antimicrobial release for the longest period (168 h, p<0.001) and exhibited the largest antimicrobial effect in an inhibition zone test using S. mutans for 7 days (p<0.05). This group had most effective physical properties and antimicrobial effects of coated elastomerics produced using a layerby-layer technique, and so its composition should be considered for use in clinical applications in orthodontics.

Premium ethylcellulose polymer based architectures at work in drug delivery

“…Patients undergoing orthodontic treatment are usually prone to plaque build-up around their appliances and enamel demineralization around their brackets because oral hygiene is more difficult for these patients (Jeon et al, 2015). Consequently, Jeon et al, 2015, Jeon et al, 2017) applied extended drug release principles to improving delivery efficiency to the particular target sites. In 2015, they developed chlorhexidine-releasing elastomerics using ethylcellulose because of it proven safety, oral cavity efficacy and release extending qualities.…”

“…In 2017, Jeon and colleagues reported further performance enhancements for the extended release chlorhexidine elastomerics by applying a layer-by-layer approach using an ethylcellulose coat. Surprisingly, this extra ethyl cellulose coat significantly prolonged chlorhexidine release and antimicrobial efficacy for 7 days (Jeon et al, 2017).…”

Numerical simulation based performance enhancement approach for an inorganic BaZrS3/CuO heterojunction solar cell

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