The Sustained Influence of Short Term Exposure to a Proprietary Extract of North American Ginseng on the Hemopoietic Cells of the Bone Marrow, Spleen and Blood of Adult and Juvenile Mice

Abstract

This study assessed the influences of CVT-E002, a proprietary extract of North American ginseng, Panax quinquefolius (Afexa Life Sciences, Inc., Edmonton, AB, Canada), in vivo, on murine hemopoietic and immune cells when administered as a dietary additive. The extract was given daily to young, adult mice for a period of 4 weeks, immediately following which one group was euthanized and the hemopoietic and immune cells of their bone marrow, spleen and blood were assayed for CVT-E002-mediated alterations in any of five cell lineages (lymphocytes, nucleated erythroid cells, granulocytes, immature granuloid precursors and monocytes). Another group of these mice was left for a subsequent 8 weeks on control diet, following which the same organs and cell lineages were analysed. In another study, juvenile mice immediately upon weaning (age: 4 weeks), were subjected to the above protocol, and their organs/cell lineages assayed. The results revealed that CVT-E002 had a long-lasting, positive quantitative effect on the lymphocytes and monocytes, regardless of age at commencement of daily, dietary CVT-E002. CVT-E002 may therefore have a prophylactic disease defense, immunostimulatory role, or potentially, even a therapeutic role.

Stimulation and Suppression of Innate Immune Function by American Ginseng Polysaccharides: Biological Relevance and Identification of Bioactives

“…AGRPS and AQ extracts are not antagonists of LPS because they have low stimulatory effect and also requires pretreatment before they can suppress LPS stimulation. The data from this study supports the reported CVT-E002 TM immunostimulatory [22,29,48,[59][60][61][62] and suppression of proinflammatory effects [21,63] under basal and induced proinflammatory conditions respectively. Therapies directed at the neutralization of proinflammatory mediators Fig.…”

Has aidi injection the attenuation and synergistic efficacy to gemcitabine and cisplatin in non-small cell lung cancer? A meta-analysis of 36 randomized controlled trials

“…Similar meta-analysis [64–65] showed that Aidi injection could decrease the toxicity induced by navelbine and cisplatin (NP) or paclitaxel and cisplatin(TP) in NSCLC. Most studies showed that Astragalus, Eleutherococcus senticosus, and Ginseng might reduce the chemotherapy related toxicity through promoting hematopoiesis [66–67] and relieving oxidative stress [68–71]. These studies provide indirect evidence for the above conclusions.…”

Pharmacological and Clinical Efficacy of American Ginseng (<i>Panax Quinquefolius</i>): A Mini Review

“…AG's extract concentrate appeared to be a potential radiation countermeasure on human peripheral blood lymphocytes administered as a dietary supplement [42]. AG's extract concentrate had a dependable, positive quantitative effect on the lymphocytes and monocytes in mice [43]. AG increased the number of natural killer cells in mice spleen and bone marrow [44].…”