The survival of childhood leukemia: An 8‐year single‐center experience

Bordbar, Mohammadreza; Jam, Nazila; Karimi, Mehran; Shahriari, Mahdi; Zareifar, Soheila; Zekavat, Omid Reza; Haghpanah, Sezaneh; Mottaghipisheh, Hadi

doi:10.1002/cnr2.1784

Cited by 3 publications

(2 citation statements)

References 36 publications

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“…In severe haemophilia cases, particularly when factor levels are below 1%, intra‐articular bleeding becomes a prevalent clinical manifestation. Whilst other joints such as the shoulder, elbow, hip and ankle may also be affected during the progression of the disease, the knee stands out as the joint most commonly prone to bleeding 4,5 …”

Section: Introductionmentioning

confidence: 99%

Morphological analysis of patellofemoral joint in haemophilic arthropathy: A case‐control study

Vahabi,

Biçer,

Kayıkçı

et al. 2024

Haemophilia

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IntroductionKnees affected by haemophilic arthropathy exhibit distinct differences in both bone morphology and soft tissue behaviour. This study aims to analyse the morphological characteristics of the distal femur and patellofemoral joint in patients with haemophilia in comparison to normal healthy population.Material and MethodsStudy was conducted as pair‐matched case‐control study with 43 individuals in both the haemophilia group and the control group. Patellar luxation, patellar tilt (PT), length of the patella in both axis (pAP, pML), depth and angle of trochlear sulcus (SD, SA), lateral trochlear inclination (LTI), medial and lateral femoral facet length (mFL, LFL), intercondylar depth (ID), transepicondylar axis (TEA) and lateral condyle length (LCL) were assessed on knee MRI. Correlation between Pettersson score and measured variables were also analysed.ResultsPT was medial sided in 10 (23.2%) cases in haemophilic group. Mean values of pAP, pML, PT were significantly lower in haemophilia group (p < .001, p: .007, p = .001 respectively). There were no significant changes in SA (p = .628), SD (p = .340), LTI (p = .685), LFL (p = .241) and MFC‐LFC (p = .770) whilst mFL was significantly longer in haemophilia group (p = .009). ID (p < .001), TEA (p = .007) and LCL (p = .001) were all shorter in haemophilia group. Pettersson score was inversely correlated with pAP, pML, ID, TEA, LCL, pML/SA and ID/LCL.ConclusionMorphological changes in haemophilic arthropathy involve a smaller and medially‐tilted patella, narrowed lateral condyle and transepicondylar axis, combined with reduced intercondylar depth. These alterations must keep in mind especially in pre‐ and intraoperative assessments for arthroplasty procedures.

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Section: Introductionmentioning

confidence: 99%

Morphological analysis of patellofemoral joint in haemophilic arthropathy: A case‐control study

Vahabi,

Biçer,

Kayıkçı

et al. 2024

Haemophilia

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“…Leukemia often presents with a range of typical symptoms such as tiredness, elevated body temperature, excessive perspiration during sleep, reduction in body weight, difficulty breathing, lightheadedness, heightened vulnerability to infections, bluish-purple skin discoloration (known as cyanosis), and indications of bleeding. In pediatric patients, the sole manifestation of discomfort could occasionally be limited to the extremities or joints (Akalın & Yumuşak, 2023;Bordbar et al, 2023;Carroll & Bhatla, 2016;Demir, 2023).…”

Section: Introductionmentioning

confidence: 99%

Development of a Simulation Environment for the Importance of Histone Deacetylase in Childhood Acute Leukemia with Explainable Artificial Inteligence

Uysal,

Kose

2023

BRAIN

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This study aims to explore new therapeutic opportunities for histone deacetylase (HDAC) inhibitors by leveraging drug repurposing approaches and analyzing their bioactivity and molecular fingerprints. The methodology includes investigating drug repurposing opportunities for HDAC inhibitors, evaluating the bioactivity of repurposing drugs on HDAC enzymes, investigating the role of HDAC genes in therapeutic effects, and analyzing molecular fingerprints with explainable artificial intelligence (XAI) to identify structurally similar compounds with potential HDAC inhibitory activity. In this context, chemical compounds with IC50 (7903 compounds) and Inhibition (1084 compounds) standard types of HDAC genes reported to be associated with childhood acute leukemia were represented by molecular fingerprints. Regression and classification models were applied to the molecular fingerprints, and the results obtained were supported by XAI. All the study results were shared interactively on the website address https://iuysal1905-childhoodacuteleukemia-drug-interacito-arayuz-r89zld.streamlit.app/ by designing a simulation environment. The influence of molecular fingerprints on the models and their impact on potential drug development in childhood acute leukemia were evaluated using XAI techniques, particularly through the analysis of SHAP values. The study contributes to the literature on the use of XAI technology in drug repurposing studies, especially in cancer, the study of molecular properties, and the active use of XAI in drug repurposing studies

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The survival of childhood leukemia: An 8‐year single‐center experience

et al. 2023

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Background The survival of childhood leukemia has improved. We aimed to report the survival rate and the associated factors in children with acute leukemia during an 8‐year follow‐up. Aims This study investigates the 8‐year survival rates of children with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) in Shiraz, the largest oncology center in Southern Iran. We also aimed to assess the independent factors associated with higher mortality in childhood leukemia. Methods Children 0–18 years with acute leukemia were followed from 2013 to 2021 in Shiraz, Iran. The 8‐year overall survival (OS) and event‐free survival (EFS) rates were estimated by the Kaplan–Meier method. Independent factors associated with survival were assessed by the Cox regression hazard modeling. Results We included 786 children, with 43.5% female, and a mean age of 6.32 ± 4.62 years. Patients with AML compared to ALL experienced more relapse (34.6% vs. 22.5%, p = .01) and death (31.7% vs. 11.3%, p < .001). The cumulative 8‐year OS and EFS were 81% (95% confidence interval (CI), 74.3% to 86.1%) and 68.3% (95% CI, 63.5% to 72.7%) in ALL patients and 63.5% (95% CI, 52.1% to 72.9%) and 43% (95% CI, 33.1% to 52.6%) in AML patients. Multivariable analysis revealed that hepatomegaly (hazard ratio = 4, 95% CI, 1.0 to 22.3, p = .05) was the main independent risk factor of death in ALL patients. No definite risk factor was defined for AML patients. Conclusion The survival of childhood leukemia has recently increased dramatically in low‐middle income countries. Hepatomegaly was introduced as a potential risk factor for lower survival in ALL patients. Further multicenter studies are needed to confirm the validity of this association.

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The survival of childhood leukemia: An 8‐year single‐center experience

Cited by 3 publications

References 36 publications

Morphological analysis of patellofemoral joint in haemophilic arthropathy: A case‐control study

Morphological analysis of patellofemoral joint in haemophilic arthropathy: A case‐control study

Development of a Simulation Environment for the Importance of Histone Deacetylase in Childhood Acute Leukemia with Explainable Artificial Inteligence

The survival of childhood leukemia: An 8‐year single‐center experience

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