The surgical relief of gastric lesions in the dog: report of seven cases

Douglas, S. W.; Lw, Hall; Walker, RG

doi:10.1136/vr.86.25.743

Cited by 8 publications

(9 citation statements)

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“…(f) Post-operative ileus. I n the authors' experience, this complication is extremely rare but Douglas, Hall & Walker (1970) emphasized its importance following gastric resection. Carlson (1967) suggested that in such cases, gas-capped fluid levels seen on erect or horizontal beam radiographs lie in the same horizontal plane, whereas numerous different levels are seen in bowel obstruction.…”

Section: Fig 20 Dachshund 3 Years Recumbent (Above) and Erect (Bementioning

confidence: 87%

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The radiological diagnosis of gastrointestinal obstruction in the dog

Gibbs

Pearson

1973

J of Small Animal Practice

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The use of contrast medium in the examination of the gastrointestinal tract is described and some aspects of the normal radiographic anatomy are discussed. The radiological features of certain conditions causing gastrointestinal obstruction are illustrated by a series of radiographs. Résumé. On décrit l'usage de substance de contraste dans l'exploration des voies gastro‐intestinales, et on discute de certaines aspects de l'anatomie radiographique normale. Les caractéristiques radiologiques de certaines particularités causant une obstruction gastro‐intestinale sont illustrées au moyen d'une série de radiographies. Zusammenfassung. Der Gebrauch von Kontrastmitteln in der Untersuchung des Verdauungskanal ist beschrieben und einige Aspekte von der normalen röntgenologischen Anatomie sind diskutiert. Die radiologischen Merkmale von gewissen Zuständen die gastrointestinale Obstruktion verursachen, sind in einer Serie vom Röntgenaufnahmen illustriert.

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Section: Fig 20 Dachshund 3 Years Recumbent (Above) and Erect (Bementioning

confidence: 87%

“…In a. review of fourteen cases, Berg, Rhodes & O'Brien (1964) identified abnormalities in only half the cases examined radiographically. Douglas, Hall and Walker (1970) recommend the use of fluoroscopy for the diagnosis of gastric neoplasia. The radiological signs are variable and depend on the site and extent of the lesion.…”

Section: The Stomachmentioning

confidence: 99%

The radiological diagnosis of gastrointestinal obstruction in the dog

Gibbs

Pearson

1973

J of Small Animal Practice

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“…Limited information is available in the veterinary literature regarding clinical outcome after surgical resection of gastric carcinoma. Studies evaluating dogs that have had surgery to treat gastric carcinoma have been restricted to case reports and case series that included multiple gastric tumor types . To the best of the authors' knowledge, there have only been 45 cases in dogs reported across 23 publications .…”

Section: Introductionmentioning

confidence: 99%

“…Studies evaluating dogs that have had surgery to treat gastric carcinoma have been restricted to case reports and case series that included multiple gastric tumor types . To the best of the authors' knowledge, there have only been 45 cases in dogs reported across 23 publications . The overall median survival time (MST) after surgery in these cases was 72 days .…”

Section: Introductionmentioning

confidence: 99%

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

et al. 2019

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Objective: To describe the clinical characteristics, perioperative complications, and outcomes in dogs surgically treated for gastric carcinoma. Study design: Multi-institutional retrospective case series. Animals: Forty client-owned dogs with histologically confirmed gastric carcinoma.Methods: Medical records were reviewed for preoperative diagnostics, surgery, histopathology, postoperative complications, adjuvant chemotherapy, disease progression, and survival. Variables were assessed for associations with outcome by using Cox proportional hazards regression analysis. Results: Surgical treatment included partial gastrectomy (28 dogs), Billroth I (9 dogs), subtotal gastrectomy (2 dogs), and submucosal resection (1 dog). Major postoperative complications occurred in 8 of 40 dogs, including septic peritonitis secondary to dehiscence in 4 dogs. The median progression free interval was 54 days, and the median survival time (MST) was 178 days (range, 1-1902). According to multivariable analysis results, experiencing an intraoperative complication was associated with an increased risk of death (hazard ratio [HR] 3.5, 95% CI 1.1-9.8, P = .005), and administration of adjuvant chemotherapy correlated with an improved survival (HR 0.4, 95% CI 0.2-0.9, P = .03). Conclusion: In this population of dogs, MST exceeded historically reported data, major postoperative complication rates were comparable to established literature, and administration of adjuvant chemotherapy was associated with improved survival.

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“…Recurrence of disease is common after resection of tumors; in dogs, survival ranges from 3 months to 5 years depending on variables such as histologic tumor type, occurrence of metastasis, and location and size of the tumor. 1,4,5,20 Human and canine gastric carcinomas have been categorized according to 3 schemes: The World Health Organization (WHO) scheme is useful but offers little prognostic significance. 11,36 The Goseki and Lauren human classifications may more accurately predict prognosis based solely on histopathologic features, 9,15,29 and the latter scheme has been successfully adapted to the dog.…”

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confidence: 99%

The Novel Carbohydrate Tumor Antigen C2-O-sLe^xIs Upregulated in Canine Gastric Carcinomas

2010

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Sialyl Lewis x-modified core 2 branched O-glycans (C2-O-sLe x ) on human leukocytes mediate much higher-affinity adhesion to selectins on activated vascular endothelium than does sialyl Lewis x on other structures. In some canine and human carcinomas, high expression of sLe x -decorated carbohydrates has been associated with metastasis and, in humans, a poor prognosis, but detection in canine gastric carcinomas is unreported. The authors hypothesized that these carbohydrates are highly expressed in more malignant types of canine gastric carcinomas, they promote metastasis, and they are associated with a poorer prognosis for dogs. The objectives were to determine the presence and importance of C2-O-sLe x expression in canine gastric carcinomas. Routine histological sections of 16 canine gastric carcinomas were categorized on the basis of 3 classification schemes: World Health Organization, Lauren, and Goseki. Serial sections were stained with antibodies directed against C2-O-sLe x (CHO-131 monoclonal antibody), cytokeratin (Lu-5 monoclonal antibody), and stains to detect neutral and acid mucins (periodic acid-Schiff and alcian blue). Whereas normal gastric mucosal epithelial cells were negative for C2-O-sLe x , 56% of the tumors examined were positive for C2-O-sLe x . Importantly, the majority of more poorly differentiated tumor types had more numerous and larger intensely stained areas of C2-O-sLe x expression compared with moderate to well-differentiated tumor types. Signet ring-type carcinomas had markedly higher distribution and intensity of periodic acid-Schiff and alcian blue staining than did tubular carcinomas. These findings suggest that C2-O-sLe x is a tumor-associated antigen that may play a role in the invasiveness and metastatic potential of certain types of canine gastric carcinomas.

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The surgical relief of gastric lesions in the dog: report of seven cases

Cited by 8 publications

References 0 publications

The radiological diagnosis of gastrointestinal obstruction in the dog

The radiological diagnosis of gastrointestinal obstruction in the dog

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

The Novel Carbohydrate Tumor Antigen C2-O-sLe^xIs Upregulated in Canine Gastric Carcinomas

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The surgical relief of gastric lesions in the dog: report of seven cases

Cited by 8 publications

References 0 publications

The radiological diagnosis of gastrointestinal obstruction in the dog

The radiological diagnosis of gastrointestinal obstruction in the dog

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

The Novel Carbohydrate Tumor Antigen C2-O-sLexIs Upregulated in Canine Gastric Carcinomas

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The Novel Carbohydrate Tumor Antigen C2-O-sLe^xIs Upregulated in Canine Gastric Carcinomas