The surgical outcomes of lung cancer combined with interstitial pneumonia: a single-institution report

Taniguchi, Daisuke; Yamasaki, Naoya; Miyazaki, Takuro; Tsuchiya, Tomoshi; Matsumoto, Keitaro; Hatachi, Go; Kakugawa, Tomoyuki; Sakamoto, Noriho; Mukae, Hiroshi; Nagayasu, Takeshi

doi:10.1007/s00595-017-1551-5

Cited by 8 publications

(5 citation statements)

References 31 publications

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“…Furthermore, AE-IP developed in 5 (3.3%) of 151 patients after pulmonary surgery in our study. This figure is similarly lower than that in previous studies (9.5–22.5%) [6–12] and also lower than in our previous study (8.5%) that was conducted at the same hospital as the present study [20]. We believe that this difference in frequency of AE-IP reflects differences in patient selection.…”

Section: Discussioncontrasting

confidence: 72%

Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study

Miyamura¹,

Sakamoto²,

Kakugawa³

et al. 2019

Respir Res

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Background Acute exacerbation of interstitial pneumonia (AE-IP) is a serious complication of pulmonary surgery in patients with IP. However, little is known about AE-IP after non-pulmonary surgery. The aim of this study was to determine the frequency of AE-IP after non-pulmonary surgery and identify its risk factors. Methods One hundred and fifty-one patients with IP who underwent pulmonary surgery and 291 who underwent non-pulmonary surgery were retrospectively investigated. Results AE-IP developed in 5 (3.3%) of the 151 patients in the pulmonary surgery group and 4 (1.4%) of the 291 in the non-pulmonary surgery group; the difference was not statistically significant. A logistic regression model showed that serum C-reactive protein (CRP) was a predictor of AE-IP in the non-pulmonary surgery group (odds ratio 1.187, 95% confidence interval 1.073–1.344, P = 0.002). Conclusions This is the first study to compare the frequency of AE-IP after pulmonary surgery with that after non-pulmonary surgery performed under the same conditions. The results suggest that the frequency of AE-IP after non-pulmonary surgery is similar to that after pulmonary surgery. A high preoperative C-reactive protein level is a potential risk factor for AE-IP after non-pulmonary surgery. Electronic supplementary material The online version of this article (10.1186/s12931-019-1128-5) contains supplementary material, which is available to authorized users.

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Section: Discussioncontrasting

confidence: 72%

Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study

Miyamura¹,

Sakamoto²,

Kakugawa³

et al. 2019

Respir Res

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“…Maniwa T et al did not found a significant correlation between blood loss and ILD ( 20 ). However, Taniguchi et al indicated that the blood loss in ILD patients suffering from acute exacerbation postoperation was greater than that in ILD patients without AE (628±338.7 vs. 272.2±451.7 mL, P=0.024) ( 21 ). We believed that combined with ILD would increase the difficulty of surgery, increase the operation time and blood loss, and might cause postoperative morbidity.…”

Section: Discussionmentioning

confidence: 99%

Impact of interstitial lung disease on postoperative morbidity and 90-day mortality after pulmonary resection

Shao¹,

Huang²,

Feng³

et al. 2020

Transl Cancer Res TCR

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Background: To evaluate the effect of interstitial lung disease (ILD) on postoperative morbidity and mortality in pulmonary resection and identify the factors of AE-ILD.Methods: We retrospectively analyzed 1,309 patients underwent pulmonary operation between January 2010 and January 2018 in our hospital. Clinical data including age, sex, history of chronic obstructive pulmonary disease (COPD), smoking history, smoking index, American Society of Anesthesiologists (ASA) classification, Charlson comorbidity index (CCI), forced expiratory volume in 1 s (FEV1) % predict, surgical procedure, video-assisted thoracoscopic surgery (VATS) or not, intraoperative blood transfusion, anesthesia time, operation time/one-lung ventilation time, blood loss, histology, postoperative morbidity, 90-day mortality, onset of acute exacerbation of ILD (AE-ILD), and postoperative stay were collected and analyzed.Results: There were 97 (7.4%) and 1,212 (92.6%) patients in the ILD and non-ILD groups, respectively. AE-ILD occurred in 6 patients (0.5%), with a mortality of 83.3%, and was the leading cause of 90-day mortality (55.6%). Age (P<0.001) was an independent risk factor for ILD. There were 6 and 91 patients in the AE-ILD and non-AE-ILD groups, respectively. ASA classification (P=0.038) were independent risk factors for AE-ILD. Multivariate regression analysis identified that the sex (P=0.003), ILD (P<0.001), COPD (P=0.007), surgical procedure (P<0.001), blood loss (P<0.001), CCI (P=0.049) were independent risk factors for postoperative morbidity. ILD (P=0.001) and postoperative morbidity (P=0.003) were independent risk factors for 90-day mortality in multivariate analysis.Conclusions: Patients with ILD had a higher incidence of postoperative morbidity and 90-day mortality.ASA classification was an important influencing factor for AE-ILD. Based on the obvious postoperative morbidity and mortality, special attention and management should be given to ILD patients.

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“…Among previous studies that examined the survival of patients with IP after undergoing NSCLC resection [ 4 , 5 , 15 - 17 ], they examined the prognostic roles of clinicopathological factors, including Krebs von den Lungen-6 (KL-6), but not tumor markers. Therefore, in the present study, we examined the prognostic significance of serum tumor markers, and found that serum CEA level might serve as an efficient prognostic indicator after surgery in NSCLC with IP.…”

Section: Discussionmentioning

confidence: 99%

Serum Carcinoembryonic Antigen Level Predicts Cancer-Specific Outcomes of Resected Non-Small Cell Lung Cancer With Interstitial Pneumonia

et al. 2018

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BackgroundIt has been well accepted that the prognosis of non-small cell lung cancer (NSCLC) patients with interstitial pneumonia (IP) is significantly poor. However, there are only a few studies that indicated the prognostic factors, especially tumor markers, among NSCLC patients with IP.MethodsForty-one NSCLC patients with IP who underwent surgery at our institution were included. Patients died of other diseases including postoperative acute exacerbation (AE) of IP were excluded. Univariate and multivariate analyses were calculated by the Cox proportional hazards regression model.ResultsThe 5-year cancer-specific survival of overall and stage I patients were 37.4% and 39.2%, respectively. The 5-year cancer-specific survival of patients with high serum carcinoembryonic antigen (CEA) level was 9.4%, while that with normal serum CEA level was 55.6%. However, serum cytokeratin-19 fragment (CYFRA 21-1) and squamous cell carcinoma-related antigen (SCC) levels were not associated with patients’ survival. Furthermore, serum CEA level was significantly associated with poorer cancer-specific survival in univariate and multivariate analyses.ConclusionsThis study demonstrated that serum CEA level might serve as an efficient prognostic indicator after surgery in NSCLC with IP.

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The surgical outcomes of lung cancer combined with interstitial pneumonia: a single-institution report

Abstract: Patients with lung cancer and IIP have a higher risk of chest surgery and a poor prognosis. Very careful surgery and perioperative management are needed, because AEs are often difficult to AE predict.

Cited by 8 publications

References 31 publications

Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study

Postoperative acute exacerbation of interstitial pneumonia in pulmonary and non-pulmonary surgery: a retrospective study

Impact of interstitial lung disease on postoperative morbidity and 90-day mortality after pulmonary resection

Serum Carcinoembryonic Antigen Level Predicts Cancer-Specific Outcomes of Resected Non-Small Cell Lung Cancer With Interstitial Pneumonia

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