The Surgical Management of Oral Cancer

Campana, John; Meyers, Arlen D.

doi:10.1016/j.otc.2005.11.005

Cited by 50 publications

(52 citation statements)

References 82 publications

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“…Relationships between clinicopathological factors were assessed using the 2 test. Factors with significant statistical differences in 2 and univariate analysis (Kaplan-Meier method) were included in a multivariate analysis using Cox proportional hazards regression. p ^ 0.05 was considered statistically significant.…”

Section: Discussionmentioning

confidence: 99%

“…Management of OSCC varies considerably; small cancers of the oral cavity are usually managed by surgery alone, whereas advanced oral cancers are usually treated with primary radical surgery followed by radiation or chemoradiation. Neck treatment is offered to patients who have a greater than 20% chance of having lymph node metastasis or who have neck involvement at the time of presentation [2] .…”

Section: Introductionmentioning

confidence: 99%

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Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence

Camisasca

Silami

Honorato

et al. 2011

ORL

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Aim: To compare the clinicopathological profile of oral squamous cell carcinoma (OSCC) in groups with and without recurrence. Methods: Records of all patients who underwent surgery for primary OSCC at a single institution during 1999 were identified. Patient demographics, lesion site, clinical and pathologic stage, pathologic grading, pattern of invasion, lymphocytic infiltrate, perineural invasion, and treatment and survival data were collected. Descriptive statistics were calculated for each variable and survival was calculated using Kaplan-Meier and Cox models. Patients were divided into 2 groups: with (n = 25) and without (n = 28) recurrence. Results: Tongue (p = 0.02) and poorly differentiated (p = 0.04) tumors were associated with recurrence. Kaplan-Meier and Cox models revealed tobacco use and the absence of lymphocytic infiltrate to be associated with the poorest survival in recurrent OSCC. Conclusion: The tumor site, tobacco use, and pathological features were involved in the recurrence of OSCC and should be taken into account for OSCC treatment and follow-up.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence

Camisasca

Silami

Honorato

et al. 2011

ORL

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“…1,2 Oral cavity and pharynx cancers are currently ranked as the sixth and eighth most prevalent cancers in the world, with squamous cell carcinomas (SCC) of the oral mucosa by far the most common type (83-90%). 3,4 It has been demonstrated that early detection of cancerous lesions generally results in reduced morbidity and mortality for some types of cancer. 4 This is important for oral cancers because cases that require substantial resection or radiation treatment can result in significant morbidity.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 It has been demonstrated that early detection of cancerous lesions generally results in reduced morbidity and mortality for some types of cancer. 4 This is important for oral cancers because cases that require substantial resection or radiation treatment can result in significant morbidity. 4 Unfortunately, oral precancerous lesions are frequently asymptomatic and can be difficult to detect at the earliest stages using current visual inspection methods.…”

Section: Introductionmentioning

confidence: 99%

“…4 This is important for oral cancers because cases that require substantial resection or radiation treatment can result in significant morbidity. 4 Unfortunately, oral precancerous lesions are frequently asymptomatic and can be difficult to detect at the earliest stages using current visual inspection methods. 5 Although the WHO classification for epithelial dysplasia is accepted by most of the oral pathologists, there is a great variability in their interpretation of the criteria.…”

Section: Introductionmentioning

confidence: 99%

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CIP2A expression and localization in oral carcinoma and dysplasia

Katz

Jakymiw

Ducksworth

et al. 2010

Cancer Biology & Therapy

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Nodal yield and survival in oral squamous cancer

Ebrahimi

Zhang

Gao

et al. 2011

Cancer

133

160

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BACKGROUND: Elective neck dissection (END) is commonly used as a staging and therapeutic procedure for oral squamous cell carcinoma (SCC) at high risk of nodal metastases. The authors aimed to determine whether the extent of lymphadenectomy, as defined by nodal yield, is a prognostic factor in this setting. METHODS: A retrospective database review identified 225 patients undergoing END with curative intent for oral SCC between 1987 and 2009. Nodal yield was studied as a categorical variable for association with overall, disease-specific, and disease-free survival in univariate and multivariate analyses. RESULTS: Nodal yield <18 was associated with 5-year overall survival of 51% compared with 74% in those with nodal yield 18 (P ¼ .009). Five-year disease-specific survival rates were 69% in those with <18 nodes and 87% in patients with 18 nodes (P ¼ .022). Similar results were obtained for disease-free survival, with 5-year rates of 44% with <18 nodes versus 71% with 18 nodes (P ¼ .043). After adjusting for the effect of age, nodal status, T stage, and adjuvant radiotherapy on multivariate analysis, nodal yield <18 was associated with reduced overall (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.1-3.6; P ¼ .020), disease-specific (HR, 2.2; 95% CI, 1.1-4.5; P ¼ .043), and disease-free survival (HR, 1.7; 95% CI, 1.1-2.8; P ¼ .040). In the pathologically lymph nodenegative subgroup (n ¼ 148), similar results were obtained. CONCLUSIONS: Nodal yield is an independent prognostic factor in patients undergoing END for oral SCC. These results suggest that an adequate lymphadenectomy in this setting should include at least 18 nodes.

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The Surgical Management of Oral Cancer

Cited by 50 publications

References 82 publications

Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence

Oral Squamous Cell Carcinoma: Clinicopathological Features in Patients with and without Recurrence

CIP2A expression and localization in oral carcinoma and dysplasia

Nodal yield and survival in oral squamous cancer

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