The Surgical and Systemic Management of Neuroendocrine Tumors of the Pancreas

Therapies for the medical management of persistent hypoglycaemia in two cases of inoperable malignant insulinoma

“…Neuroendocrine tumours of the pancreas occur infrequently, with an incidence of 1-1.5 per 100 000 in the United States (1). Of those, 20-30% are insulinomas (2), the vast majority being benign.…”

Surgical Resection and Multidisciplinary Care for Primary and Metastatic Pancreatic Islet Cell Carcinomas

“…1,2 The combination of low incidence and sporadically uncharacteristic clinical behavior has precluded the controlled evaluation and development of multimodal treatment regimens. [3][4][5] However, the optimal management of gastrointestinal malignancies has increasingly necessitated multidisciplinary approaches with input from both medical and surgical specialties. Our objective was to examine the multidisciplinary management of patients with ICC within a large population-based cancer registry to determine the role of surgical and medical therapies in the management of ICC.…”

18F-FDOPA: A Multiple-Target Molecule

“…Typically, patients with NETs present with advanced disease because the primary lesion may remain clinically silent and small despite multiple-organ metastases. Although curative surgical treatment can be offered only to a minority, recent studies indicate that successful cytoreductive surgery can both effectively control symptoms and potentially improve outcome (3). Nonsurgical treatment of NETs consists of somatostatin analogs, radiofrequency ablation, chemotherapy, and biologically active substances that can alleviate symptoms related to hormone secretion and sometimes affect disease progression (4).…”