The supplementation of pasak bumi (Eurycoma longifolia Jack.) in undernourished rats to increase spatial memory through antioxidant mechanism

Triawanti,; Sanyoto, Didik Dwi; Noor, Meitria Syahadatina

doi:10.1016/j.yclnex.2020.08.002

Cited by 6 publications

(7 citation statements)

References 21 publications

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“…This study proved that the administration of 15 mg/kg BW of EPB and 1 mg/kg BW of DHA was able to increase the activity of SOD and catalase. Pasak bumi used in this study contains flavonoid compounds of 42.28 mg/mL which act as antioxidants [7]. Flavonoids can reduce oxidative stress through mechanisms (1) directly as ROS scavengers;…”

Section: Discussionmentioning

confidence: 99%

“…(2) chelating free radicals by donating hydrogen atoms or by single-electron transfer; (3) chelation of transition metal elements; (4) inhibiting enzymes that generate free radicals; and (5) induces other internal antioxidant enzymes [14]. Triawanti et al proved that the 15 mg/kg BW ethanol extract of pasak bumi has the potential to increase enzymatic antioxidant activity higher than the dose of 7.5 mg/kg BW [7].…”

Section: Discussionmentioning

confidence: 99%

“…Each group consisted of five rats. The use of EPB at a dose of 15 mg/kg BW based on the results of the previous studies which showed the best antioxidant potential compared to a dose of 7.5 mg/kg BW [7].…”

Section: Preparation Of Experimental Animal Malnutritionmentioning

confidence: 99%

“…DHA can reduce ROS-induced DNA damage in aortic endothelial cells and reduce H 2 O 2 [6]. In addition to providing adequate nutrition, research has proven that administration of 70% ethanol extract of pasak bumi can reduce oxidative stress in the brain of undernourished rats [7]. However, there has been no research on the combination of pasak bumi, seluang fish as a source of protein, and DHA which strengthens the antioxidant effect in the brain.…”

Section: Introductionmentioning

confidence: 99%

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Potential Combinations of Pasak Bumi (Eurycoma longifolia Jack), Docosahexaenoic Acid, and Seluang Fish (Rasbora spp.) to Improving Oxidative Stress of Rats (Rattus norvegicus) Brain Undernutrition

Sanyoto¹,

Noor

Triawanti

2022

Open Access Maced J Med Sci

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BACKGROUND: The brain is very susceptible to damage from oxidative stress due to undernutrition. Provision of nutrients and compounds that act as antioxidants is needed to improve oxidative stress in the brain. AIM: This study was conducted with the aim of proving the potential of the combination of pasak bumi (Eurycoma longifolia Jack), DHA, and seluang fish (Rasbora Spp.) to improve oxidative stress in the brains of undernourished rats (Rattus norvegicus). METHODS: Once the rats were undernourished, they were divided: positive control (KP) = undernourished rats + placebo + standard feed; (P1) = undernourished rats + 70% ethanol extract of pasak bumi root (EPB) 15 mg/kg BW + standard feed; (P2) = undernourished rats + DHA 1 mg/kgBW + standard feed; (P3) = undernourished rats + EPB 15 mg/kg BW + DHA 1 mg/kg BW + standard feed; (P4) = undernourished rats + seluang fish; (P5) = undernourished rats + EPB 15 mg/kg BW + seluang fish for 5 weeks; plus 1 negative control group (KN) that is healthy rats given placebo and standard feed. The parameters included superoxide dismutase (SOD) activity, catalase, peroxide (H2O2) and malondialdehyde (MDA) levels. Data analysis used the Kruskall-Wallis test followed by Mann Whitney with a significance level of 95%. RESULTS: There were significant differences in the activity of SOD (p = 0.001), catalase (p = 0.000), peroxide levels (p = 0.000), and MDA (p = 0.000) between treatments. The group that was given a combination of EPB 15 mg/kg BW and DHA 1 mg/kg BW showed better SOD and catalase activity, and lower levels of peroxide and MDA than the other groups. CONCLUSION: The combination of 70% ethanol extract of pasak bumi 15 mg/kg BW and DHA 1 mg/kg BW has the best potential to improve brain oxidative stress in undernourished rats compared to single administration of 15 mg/kg BW EPB, DHA, or seluang fish alone.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Experimental Animal Malnutritionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential Combinations of Pasak Bumi (Eurycoma longifolia Jack), Docosahexaenoic Acid, and Seluang Fish (Rasbora spp.) to Improving Oxidative Stress of Rats (Rattus norvegicus) Brain Undernutrition

Sanyoto¹,

Noor

Triawanti

2022

Open Access Maced J Med Sci

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“…Administration of 70% ethanol extract of E. longifolia root proved increase SOD (Super Oxidant Dismutase) levels and reducing MDA (Malondialdehyde) levels. E. longifolia contained lavonoid, alkaloid, phenols and glycoside which were known to have antioxidant activity (Triawanti et al, 2020). Flavonoid has a role as free radical scavenger and stimulating antioxidant enzymes.…”

Section: Antioxidant Activitymentioning

confidence: 99%

A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia

Insanu¹,

Pratiwi²,

Fidrianny³

2021

ijrps

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Eurycoma longifolia belongs to Simaroubaceae family. It is a tall tree and has different local name from many countries and this review consisted of their traditional usage, phytochemical compounds and pharmacological activity. A systematic review was conducted to study the scientific work of E. longifolia which published in the last 10 years and minimum 20 articles that published in the last 2 years, published in Pubmed, Scopus etc. also has a digital object identifier (DOI). E. longifolia was a popular traditional medicine. The leaves wasused as supplement for giving birth, its bark as anthelmintic and its roots as antimalaria, laxative, antidiabetic etc.Due to high demand of this plant there are various formula of E. longifolia available in health food market. Many studies have been performed to determine the active constituents and pharmacology activities of E. longifolia. Alkaloid, quassinoid, polyphenols, flavonoid, polysaccharide, triterpenoid were found in E. longifolia. Quassinoids is a major phytochemical compound in E. longifolia which has various types like eurycumanone, eurycomanol, eurycomadilactone and eurylactone. Quassinoids has bitter taste and often found in Simaroubaceae family.Pharmacological activities of E. longifolia such as anti-inflammatory, analgesic, antioxidant, antimicrobial, antidiabetic, anti-osteoporotic activities. The literature review results showed that E. longifolia can be considered as medicinal plant for human. In the future, further studies on mechanism of pharmacology activity of E. longifolia are warranted.

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The role of selected flavonoids from bajakah tampala (Spatholobus littoralis Hassk.) stem on cosmetic properties: A review

Sianipar

Suryanegara

Fatriasari

et al. 2023

Saudi Pharmaceutical Journal

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The supplementation of pasak bumi (Eurycoma longifolia Jack.) in undernourished rats to increase spatial memory through antioxidant mechanism

Cited by 6 publications

References 21 publications

Potential Combinations of Pasak Bumi (Eurycoma longifolia Jack), Docosahexaenoic Acid, and Seluang Fish (Rasbora spp.) to Improving Oxidative Stress of Rats (Rattus norvegicus) Brain Undernutrition

Potential Combinations of Pasak Bumi (Eurycoma longifolia Jack), Docosahexaenoic Acid, and Seluang Fish (Rasbora spp.) to Improving Oxidative Stress of Rats (Rattus norvegicus) Brain Undernutrition

A review of the phytochemical compounds and pharmacological activities of Eurycoma longifolia

The role of selected flavonoids from bajakah tampala (Spatholobus littoralis Hassk.) stem on cosmetic properties: A review

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