The Suitability of Kahn Antigens for the Technique Used in the Citochol Reaction

Abstract

speaking from the bacteriological standpoint, said that experiments made so far proved that it was impossible to make any organism which was susceptible to penicillin, penicillinfast. There was no reason to believe that penicillin acted in the same way as did the sulphonamides, so that the experiment suggested by Lloyd Jones and Maitland was to be recommended.One matter which was not known was the clinical level of penicillin which was efficient. All efforts to determine this had failed, and the level which was used and which was found as the result of bacteriological examination-and the blood level of penicillin could be determined only by bacteriological examination-was empirical. Investigation in the United States of America had shown that levels undetectable in the blood by means of bacteriological examination were nevertheless clinically effective and efficient. It would seem that to give these massive doses of penicillin, although the excretion was completed after 8-10 hours, would ensure that for many hours penicillin was present, although undetectable, and was doing some good in the body.Work was being done on similar lines in other diseases and similarly good results were being obtained. It would seem that these 3-hourly or 4-hourly injections were given because a high blood level was expected, but that it might be unnecessary with penicillin.