2008
DOI: 10.1038/nm.1873
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The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

Abstract: Vascularization is essential for tissue development and in restoration of tissue integrity after an ischemic injury. In studies of vascularization, the focus has largely been placed on vascular endothelial growth factor (VEGF), yet other factors may also orchestrate this process. Here we show that succinate accumulates in the hypoxic retina of rodents and, via its cognate receptor G protein-coupled receptor-91 (GPR91), is a potent mediator of vessel growth in the settings of both normal retinal development and… Show more

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Cited by 329 publications
(392 citation statements)
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“…Retinal neurons contribute to the formation of retinal vessels both in physiological and pathological conditions (Sapieha et al, 2008;Usui et al, 2015). Retinal neurons are also suggested to act on hyaloid vasculature (Xu et al, 2004;Kurihara et al, 2010), in part by secreting VEGF (Rao et al, 2013).…”
Section: Res Ults and Discussionmentioning
confidence: 99%
“…Retinal neurons contribute to the formation of retinal vessels both in physiological and pathological conditions (Sapieha et al, 2008;Usui et al, 2015). Retinal neurons are also suggested to act on hyaloid vasculature (Xu et al, 2004;Kurihara et al, 2010), in part by secreting VEGF (Rao et al, 2013).…”
Section: Res Ults and Discussionmentioning
confidence: 99%
“…Succinate has been shown to play an important role in hypoxia-induced retinal neovascularization (Sapieha et al, 2008). In a 2008 milestone study, Sapieha et al demonstrated that, in case of oxygen deprivation, the activation of SUCNR1 at the surface of RGC triggered the release of pro-angiogenic factors such as VEGF and angiopoietins (Sapieha et al, 2008).…”
Section: Retinal Angiogenesismentioning
confidence: 99%
“…In a 2008 milestone study, Sapieha et al demonstrated that, in case of oxygen deprivation, the activation of SUCNR1 at the surface of RGC triggered the release of pro-angiogenic factors such as VEGF and angiopoietins (Sapieha et al, 2008). Furthermore, it was established that SUCNR1 activation promoted retinal angiogenesis in both normal retina and ischemic proliferative retinopathies (Sapieha et al, 2008).…”
Section: Retinal Angiogenesismentioning
confidence: 99%
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“…Ces cellules neuronales sont le siège de la plus haute activité métabolique de la rétine interne [7]. Il serait donc concevable que lors d'une ischémie rétinienne, ces cellules ganglionnaires via la production de succinate et l'activation de GPR91, stimulent la croissance vasculaire pour rétablir l'équilibre énergétique (Figure 1b) [8]. En accord avec cette hypothèse, nous avons observé qu'une injection intraoculaire de succinate augmente considérablement la croissance vasculaire rétinienne (Figure 2a) [8].…”
Section: Gpr91 : Récepteur De Succinate Et Maître Régulateur De L'angunclassified