L’offre et la demande : l’influence du métabolisme énergétique sur l’angiogenèse

Sapieha, Przemysław; Zaniolo, Karine; Hamel, David; Joyal, Jean‐Sébastien; Chemtob, Sylvain

doi:10.1051/medsci/2009254346

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Hypoxia, resulting from structural vessel abnormality, reduces the energy metabolism provided by the Krebs cycle, thus leading to an accumulation of succinate. The latter binds to the GPR91 receptor and stimulates the vessel growth [59]. Hypoxia allows the recruitment of bone marrow-derived immune cells to tumor sites, including TAMs, neutrophils, mast cells, and myeloid-derived suppressor cells.…”

Section: Mechanisms Of Angiogenic Hijackingmentioning

confidence: 99%

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Penco-Campillo

Pagès

Martial

2023

Biology

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Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB is highly vascularized, and both angiogenesis and lymphangiogenesis are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways.

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Section: Mechanisms Of Angiogenic Hijackingmentioning

confidence: 99%

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Penco-Campillo

Pagès

Martial

2023

Biology

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“…Les néo-vaisseaux tumoraux défectueux participent eux aussi à créer un environnement métabolique et immunitaire unique [24]. En effet, l'angiogenèse tumorale participe à l'augmentation de l'afflux en oxygène et en nutriments, dont l'apport par simple diffusion n'est plus suffisant à la croissance de la tumeur (l'oxygène ne peut diffuser passivement que sur de courtes distances, de l'ordre d'une centaine de micromètres).…”

Section: Les Anomalies De L'angiogenèse Tumoraleunclassified

L’angiogenèse tumorale

Treps

Gavard

2015

Med Sci (Paris)

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L’offre et la demande : l’influence du métabolisme énergétique sur l’angiogenèse

Cited by 2 publications

References 8 publications

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

L’angiogenèse tumorale

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