The Successful Treatment of Intraurethral Condyloma Acuminata with Colchicine

Gigax, John H.; Robison, Jack R.

doi:10.1016/s0022-5347(17)61636-7

Cited by 26 publications

(6 citation statements)

References 11 publications

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“…As demonstrated in earlier studies (2,3,4) there is a !arge placebo response in recurrent herpes simplex, presenting a considerable pitfall to clinical trials. Also, due to the great interand intra-indi vidual variations in the frequency and course of recurrent herpes, evaluation of a prophylactic treatment presents great investigational problems; it requires large patient materials, long observation periods and makes the employment of double-blind, controlled trials absolute I y necessary.…”

supporting

confidence: 52%

Topical treatment of penile condylomata acuminata with colchicine at 48-72 hours intervals

Krogh¹,

Rudén²

1980

Acta Derm Venereol

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We previously demonstrated that 8% solutions of colchicine in ethanol eradicated penile warts in 36% of patients after a single application and in an additional 12% after a second application performed at least a week after the first. In the present study only 30% of 115 men were cured when penile warts were painted twice at intervals of 48 hours with 2% solutions and 72 hours with 4% and 8% solutions of colchicine. The lack of additive therapeutic effect accruing from the second application and the high frequency of intolerable side effects when using the latter treatment program indicate that this regimen is unsuitable for condylomata therapy.

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supporting

confidence: 52%

Topical treatment of penile condylomata acuminata with colchicine at 48-72 hours intervals

Krogh¹,

Rudén²

1980

Acta Derm Venereol

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“…Colchicine (COL) is a natural alkaloid compound derived mainly from the medicinal plant Colchicum automnale and has been used in the clinic for treating gout and familial Mediterranean fever. COL has also shown some benefit in primary biliary cirrhosis [1], amyloidosis [2], and condyloma acuminate treatments [3]. COL is an antimitotic drug, which interferes strongly with cell division by affecting microtubule assembly and disassembly during mitosis.…”

Section: Introductionmentioning

confidence: 99%

Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles

AbouAitah

Hassan

Świderska-Środa

et al. 2020

Cancers

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Antimitotics are important anticancer agents and include the natural alkaloid prodrug colchicine (COL). However, a major challenge of using COL as an anticancer drug is its cytotoxicity. We developed a novel drug delivery system (DDS) for COL using mesoporous silica nanoparticles (MSNs). The MSNs were functionalized with phosphonate groups, loaded with COL, and coated with folic acid chitosan-glycine complex. The resulting nanoformulation, called MSNsPCOL/CG-FA, was tested for action against cancer and normal cell lines. The anticancer effect was highly enhanced for MSNsPCOL/CG-FA compared to COL. In the case of HCT116 cells, 100% inhibition was achieved. The efficiency of MSNsPCOL/CG-FA ranked in this order: HCT116 (colon cancer) > HepG2 (liver cancer) > PC3 (prostate cancer). MSNsPCOL/CG-FA exhibited low cytotoxicity (4%) compared to COL (~60%) in BJ1 normal cells. The mechanism of action was studied in detail for HCT116 cells and found to be primarily intrinsic apoptosis caused by an enhanced antimitotic effect. Furthermore, a contribution of genetic regulation (metastasis-associated lung adenocarcinoma transcript 1 (MALAT 1), and microRNA (mir-205)) and immunotherapy effects (angiopoietin-2 (Ang-2 protein) and programmed cell death protein 1 (PD-1) was found. Therefore, this study shows enhanced anticancer effects and reduced cytotoxicity of COL with targeted delivery compared to free COL and is a novel method of developing cancer immunotherapy using a low-cost small-molecule natural prodrug.

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“…However, the treatment failures with this method, especially among patients with meatal warts, constitute a considerable problem (Halverstadt and Parry, 1969;Gigax and Robison, 1971). Some of these failures may be explained by condylomata situated within the urethra, which can easily be overlooked.…”

Section: Introductionmentioning

confidence: 99%

5-Fluorouracil in the treatment of penile and urethral condylomata acuminata.

Wallin¹

1977

Sexually Transmitted Infections

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SUMMARY 5-Fluorouracil (5-FU) cream was compared with podophyllin 25 % in alcohol for treating genital and urethral condylomata acuminata. The cure rate after four weeks was found to be 6 of 18 patients treated with 5-FU and 10 of 19 treated with podophyllin. By changing the treatment for those notcured, warts regressed afterfour weeks infour more patientsin each group. Patients were followedup for four to nine months; 10 of 27 treated with 5-FU and 14 of 31 treated with podophyllin remained in remission. It is not possible to support earlier reports on the successful treatment of meatal warts using 5-FU cream. More than half of the patients given 5-FU reported side effects after 10 to 14 days' treatment, which in some cases led them to stop using the cream. Twenty-one men considered to be treatment failures or relapses were examined by urethroscopy. No intraurethral condylomata were found but three cases of warts in the fossa navicularis were discovered; this prompted us to introduce an instrument to examine the urethral meatus and the fossa navicularis.

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The Successful Treatment of Intraurethral Condyloma Acuminata with Colchicine

Cited by 26 publications

References 11 publications

Topical treatment of penile condylomata acuminata with colchicine at 48-72 hours intervals

Topical treatment of penile condylomata acuminata with colchicine at 48-72 hours intervals

Targeted Nano-Drug Delivery of Colchicine against Colon Cancer Cells by Means of Mesoporous Silica Nanoparticles

5-Fluorouracil in the treatment of penile and urethral condylomata acuminata.

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