The Submicroscopical Structure of the Reticular Cell Tissue

Fresen, Otto

doi:10.1159/000209587

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that Alk-Pase can be induced in cultured fibroblasts (26), and that this enzyme may be indicative of collagen synthesis (18,(26)(27)(28)(29). The possibility that reticulum cells are the source of the intercellular reticulum fibers in the bone marrow has long been postulated (30), and was re-emphasized by Weiss (4). The presence of Alk-Pase on the plasma membrane would then merely reflect a certain functional state of the fibroblast-like nonphagocytic reticulum cell observed by others (4,(6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Association of alkaline-phosphatase-positive reticulum cells in bone marrow with granulocytic precursors.

Westen¹,

Bainton²

1979

The Journal of Experimental Medicine

218

103

View full text Add to dashboard Cite

In the bone marrow, an elaborate stroma forms the structural basis of the hemopoietic microenvironment. In this study, two different types of stromal cells were identified with certainty on tissue sections of intact bone marrow of rats and mice using light and electron microscopic histochemistry: (a) a fibroblast-type of reticulum cell which is characterized by having alkaline phosphatase associated with its plasma membrane. We refer to this cell as the alkaline-phosphatase-positive reticulum cell (Al-RC). It is closely associated with granulocytic precursors, particularly myeloblasts and neutrophilic promyelocytes. These reticulum cells may be found throughout the marrow but are concentrated near the endosteum. (b) a macrophage-type of reticulum cell which is characterized by its abundance of lysosomal acid phosphatase and is mainly associated with erythroid precursors (as observed by others). In contrast to the above-mentioned cell type, this latter cell was found to be distributed uniformly throughout the marrow. We speculate that the Al-RC are mesenchymal stromal cells necessary for granulocytic differentiation in bone marrow.

show abstract