Abstract:Background: Brugada syndrome is a hereditary disease with genetic and phenotypic variability characterized by a high risk for arrhythmia and sudden cardiac death. It is assumed that modifying genetic factors contribute to the variability of the phenotype. Mitochondrial DNA (mtDNA) polymorphism can be considered among such factors, since mitochondrial dysfunction, including that associated with mtDNA variants, can have an arrhythmogenic effect. Aim: To study possible association between mtDNA polymorphism with… Show more
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