The Study of the Effect of Histidine Derivatives as a Novel Antinociceptive and Anti‐Inflammatory Activity

Abstract

This study explains the biochemical activity of histidine derivatives The compounds were identified by CHN analysis, FT-IR and H1NMR. The results certified that the chemical structures of the prepared compounds. The anti-inflammatory and antinociceptive activity was studied by two different tests; the hot plate test and writhing test for analgesic activity and two tests for anti-inflammatory activity they are formalin induced inflammation test and carrageen an induced inflammation test. The histidine derivatives were found to have potent activity as anti-inflammatory and antinociceptive. The active compounds were tested to acute toxicity. It was found that they are safety to the dose 5 g/kg orally in mice without any mortality.

Bioactive Components of Meat Powder and Viscera-Gonad Holothuria Scabra from Terung Island Waters, Batam, Indonesia

“…That histidine has antiinflammatory activity and pain relief (antinociceptive), even the amino acid histidine which is an essential amino acid for infants and not needed by adults. This amino acid type is also found in sea cucumber proteins [42].…”

Synthesis of Imidazole and Histidine-Derived Cross-Linkers as Analogues of GOLD and Desmosine

“…The synthesis of histidine-based precursors 20 and 21 via N-protected histidine methyl esters 19a,b, [22][23][24] which were prepared from L-histidine (11c), is shown in Scheme 4.…”