The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA₂Synthase

Abstract

The pyridazine moiety is an important structural feature of various pharmacological active compounds. Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is, inhibitors of prostaglandin or cyclooxygenase (COX-I & COX-II) enzyme, platelet cAMP phosphodiesterase, and thromboxane A2 (TXA2) synthase. These compounds are selective and nonselective COX inhibitors and showed analgesic, anti-inflammatory, and antipyretic activity. Pyridazine compounds with antiplatelet agents inhibited TXA2enzyme. Pyridazines also exhibited antirheumatoid activity. These pyridazine compounds hold considerable interest relative to the preparation of organic intermediates and other anticipated biologically active compounds.

A Review on Pyridazinone Ring Containing Various Cardioactive Agents

“…Pyridazinone derivatives have gained substantial attention within the field of medicinal chemistry. Pyridazine moiety has been tested extensively for its diverse biological activities including antiinflammatory, analgesic, anticancer, antiviral, antimicrobial, cardiovascular, antitubercular, antiobesity, antidiabetic, neuroprotective, and various other activities [90][91][92][93][94][95][96]. Cardiovascular diseases (CVDs) are the leading reason for death worldwide and remain the leading reason for avoidable death worldwide.…”

Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus

“…The easy functionalization at various ring positions makes them an attractive synthetic building block for designing and synthesis of new drugs. Pyridazines are widely recognized as versatile scaffolds with a diverse set of biological activities [12][13][14][15] . Among pyridazine derivatives, pyridazinones is an important class of compounds mainly due to their diverse biological activities like analgesic, anti-inflammatory, antibacterial, herbicidal, antifungal, antituberculotic, anti-AIDs, antitumour, antihypertensive, anticonvulsant, anticancer, and antiviral activities [16][17][18][19][20] .…”

Synthesis and biological screening of some novel 6‐substituted 2‐alkylpyridazin‐3(2H)‐ones as anti‐inflammatory and analgesic agents

“…[1,6] The recent drug discovery efforts have been oriented toward developing novel small molecule ring templates as NSAIDs and selective COX-2 inhibitors. [7] The pyridazin-3-one moiety has a diverse set of biological activities.A wide range of biological activities was recorded for pyridazine derivatives such as antiangiogenic, [8] anticancer, [9] antimicrobial, [10] analgesic, [10,11] antidepressant, [12] antihypertensive, [13] antifungal, antifeedant, [14] phosphodiesterase-4 (PDE4) inhibitors are effective antiinflammatory, selective COX-2 inhibitors, [15,16] and antiplatelet [17] activities. Various drugs include pyridazinone ring as a core nucleus like sulmazole, levosimendan, amipizone, indolidan, imazodan, pimobendan, emorfazone, zardaverine, and milrinone.…”