Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus

Abstract

Pyridopyridazine compounds are important nitrogen atom containing heterocyclic compounds due to their pharmacological versatility. This heterocycle system characterized a structural feature for different types of bioactive compounds that exhibiting various types of biological activities which make it an attractive scaffold for the design and development of new drug molecules. This article provided information about the pharmacological properties of pyridopyridazines derivatives.

A Review on Pyridazinone Ring Containing Various Cardioactive Agents

“…Pyridazinone derivatives have gained substantial attention within the field of medicinal chemistry. Pyridazine moiety has been tested extensively for its diverse biological activities including antiinflammatory, analgesic, anticancer, antiviral, antimicrobial, cardiovascular, antitubercular, antiobesity, antidiabetic, neuroprotective, and various other activities [90][91][92][93][94][95][96]. Cardiovascular diseases (CVDs) are the leading reason for death worldwide and remain the leading reason for avoidable death worldwide.…”

Pharmacological activities of pyridazines and pyridazinone Derivatives: A Review on biologically active scaffold

“…Likewise, these are found to be associated with significant industrial uses, potential biological and physiological activities. Accordingly a massive research effort has been expended the novel congeners bearing these biologically active structural moieties within a molecular framework likely to constitute potent pharmacological agents [4,5,6]. Polysubstituted pyridazinones from tetrafluoropyridazine and 4,5,6-trifluoropyridazin-3(2H)-one can be used for the synthesis of various substituted and ring-fused pyridazinones.…”

“…The pyridazine and pyridazinone compounds have been reported as diverse pharmacological active compounds. Substantial number pyridazine and pyridazinone derivatives represent an important class of biologically active compounds and possess interesting wide spectrum of biological activities such as antimicrobial, antiviral, antibacterial, antifungal, analgesic, anti-inflammatory, antifeedant, herbicidal [1][2][3], antihypertensive, antiplatelet, anticancer, antipyretics, cardiovascular, antitubercular, anticonsulvant, intermediates for drugs and agrochemicals and other anticipated pharma-cological activities [4][5][6]. Pyridazine and pyridazinones drew our interest because of their easy functionalization at ring, which makes them effective compounds for designing and development of novel pharmacotherapeutic agents.…”

“…The dual inhibition of cyclooxygenase (COX) and 5-lypoxygenase (LOX) enzymes for treatment of inflammation and pain, [6-(4-methoxyphenyl)-3(2H)-pyridazinone-2-yl] acetamide and propanamides and of 3-[1-(3-pyridazinyl)-5-phenyl-1H-pyrazole-3yl]propanoic acids (4) were showed potential analgesic activity. Some studies for developing COX-2 inhibitors have concentrated on the amide derivatives of currently used NSAIDs and these compounds selectively inhibited COX-2 but not COX-1.…”

A Facile Solid-State Synthesis and Antimicrobial Activity Studies on Some Piperidone Derivatives

“…Nitrogen inserted heterocycle have a chief position in organic as well as in medicinal chemistry because of the useful properties of many members of these compounds. [1][2][3] Over the piperidine derivatives are one of the most widely studied class of heterocyclic compounds and have usual attention as a source of new and useful pharmaceuticals and biologically active compounds, Piperidone compounds possess important biological properties, including analgesic, 4 antioxidant, 5 antibacterial, 6 antituberculosis, 7 antifungal, 8 anti-inflammatory 9 and also anticancer. [10][11][12][13] Phenyl ring are substituted piperidone, display a number of exciting pharmacological possessions.…”