The Study of in vitro and in vivo Effects of Concurrent Administration of Paracetamol and Zinc on the Antibacterial Activity of Ciprofloxacin

Abstract

Concurrent administration of more than one drug is a common practice in medical science and in such case one drug may affect the pharmacology of another drug. Ciprofloxacin is a commonly used antibiotic in Bangladesh and frequently prescribed with paracetamol and zinc salt for concomitant use in patients suffering from infections. Therefore, the interaction of ciprofloxacin with paracetamol and zinc salt was studied in vitro at pH 1.2, 6.8 and 7.4 which are related to gastric, intestinal juices and blood environment, respectively. In vitro evaluation of ciprofloxacin complexes with paracetamol and zinc was carried on several gram positive and gram negative microorganisms by disc diffusion method. The in vivo effect of the complexes was assessed by determining the plasma concentration in mice by spectroscopic method. It was observed that in the in vitro study paracetamol and zinc has insignificant effect on the antibacterial activity of ciprofloxacin although zinc itself showed some antibacterial activity; and in the in vivo study it was found that zinc sulphate reduced the bioavailability of ciprofloxacin HCl.

In vitro Interaction of Metformin with Diclofenac in Aqueous Medium

“…Thus, it could be infared that a good number of combination products might resulted due to interaction of metformin with diclofenac. These results are comparable to some of our previous studies [8][9][10][11] where simultaneous administration of two or more drugs have been discouraged for the safety of the patient because, in our country, clinical monitorings, even in big hospitals, are rarely performed.…”

Evaluation of in vitro Interaction of Metformin with Ibuprofen in Aqueous Medium

“…Thus, it can be said that a good number of combination products might result due to interaction of metformin with ibuprofen. These results are comparable to the previous studies Ahsan et al, 2011Ahsan et al, , 2012Siraji et al, 2012).…”

Studies of Interactions of Valsartan, Glimepiride and Ciprofloxacin HCl by DSC and HPLC

“…However, to take any step to manage the problems of informations the nature of interaction should be known (Ahsan et al, 2011). For the drugs which are being used conventionally, interaction studies are also very important to detect the problems yet to be known.…”