The study of dual COX-2/5-LOX inhibitors by using electronic-topological approach based on data on the ligand–receptor interactions

Aksakal, Fatma Nur; Shvets, N.; Димогло, А. С.

doi:10.1016/j.jmgm.2015.06.006

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…This study has indicated that thiazole-possessing compound 14 remarkably decreased the neurotoxicity induced by ROS at 10 µM concentrations. In addition, the mentioned compound showed the best lipid peroxidation (LPO) inhibition and in vivo neuroprotective activities using gerbils as animal models [117,118]: (13), (14). Thiazole derivatives and related compounds reported as antioxidant agents.…”

Section: Antioxidant Agentsmentioning

confidence: 99%

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

2023

Nanosistemi, Nanomateriali, Nanotehnologii

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1.3-thiazole is a unique heterocycle containing nitrogen and sulphur atoms. Thiazole chemistry has developed after the pioneering it of Hofmann and Hantzsch in 1887. Thiazole occupies an important place in medicinal chemistry. It is widely found in diverse pharmacologically active substances and in some naturally occurring compounds. In last decade, heterocyclic compounds containing thiazole moiety and their derivatives were found exhibiting nanoscale properties. In addition, they exhibit a wide spectrum of biological activities such as antioxidant, antitubercular, antiinflammatory, anti-HIV, antitumor, anticonvulsive, antifungal and antibacterial. Thiazole is an essential in many natural (vitamin B 1 -thiamine) and synthetic medicinally important compounds. This review focus on both the chemical and biological importance of thiazole as a nanoparticle and the different methods of synthesis of substituted thiazole with potential activities, which are now in developing phase.1.3-тіазол є унікальним гетероциклом, що містить атоми Нітроґену та Сульфуру. Тіазолева хемія розвинулася після започаткування неї Гофманном і Ганчшем у 1887 році. Тіазол займає важливе місце в лікарській хемії. Він широко зустрічається в різних фармакологічно активних речовинах і в деяких природніх сполуках. В останнє десятиліття було виявлено, що гетероциклічні сполуки, які містять тіазолову частину, та їхні похідні проявляють нанорозмірні властивості. Крім того, вони проявляють широкий спектер біологічних дій, таких як антиоксидант-

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Section: Antioxidant Agentsmentioning

confidence: 99%

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

2023

Nanosistemi, Nanomateriali, Nanotehnologii

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“…COX2 and LOX-5 mediated biosynthesis of AA-DLMs, plays an important role in the inflammation process, which occur in different conditions including rheumatoid arthritis, neuroinflammation and psoriasis [53e55]. Due to the contribution of COX-2 and LOX-5 in the inflammatory process, there is a large interest in the use of new drugs as inhibitors of these oxygenase enzymes [56,57]. Recently, the upregulation of COX-2 was reported in situations where antiangiogenic therapies were applied, specifically in treatment with anti-VEGFR-2 antibodies and sunitinib.…”

Section: Cyclooxygenase 2 (Cox-2) and 5-lipoxygenase (Lox-5)mentioning

confidence: 99%

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

et al. 2018

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a b s t r a c tAngiogenesis is the natural and physiologic process of growing blood vessels from pre-existing ones. Pathological angiogenesis occurs when the precise balance of all the molecular pathways that regulate angiogenesis is disrupted, and this process is a critical step in many diseases, including cancer. A limited number of antiangiogenic synthetic drugs have been developed. However, due to toxicity and side effects issues, the search for alternative to existing drugs is ongoing. In this sense, natural molecules obtained from plants or macrofungi, have demonstrated extraordinary potential in the treatment of angiogenesisrelated pathologies, specially taking into consideration its absence or very low toxicity, when compared to synthetic drugs. Using natural compounds as potential angiogenesis modulators is thus a promising field of research, supporting the creation of novel therapies able to reduce the use of drugs and associated side effects. In this review, the current status of antiangiogenic drugs and the wide variety of natural extracts and molecules with antiangiogenic capacities, as well as the angiogenesis molecular pathways and therapeutic targets, are presented. Finally, the challenges that need to be overcome in order to increase the use of natural compounds for clinical purposes are discussed.

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Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

Manju

Ethiraj

et al. 2018

European Journal of Pharmaceutical Sciences

117

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The study of dual COX-2/5-LOX inhibitors by using electronic-topological approach based on data on the ligand–receptor interactions

Cited by 4 publications

References 42 publications

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

Systematic Review on Thiazole Compounds as Nanoparticles: Chemistry, Synthesis, Antimicrobial Activities, Therapeutic Investigation

Antiangiogenic compounds: well-established drugs versus emerging natural molecules

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

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