1965
DOI: 10.1021/ja01082a031
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The Structures of Aflatoxins B and G1

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Cited by 208 publications
(75 citation statements)
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“…Aflatoxin B 1 was discovered in the early 1960s as the etiological agent of 'Turkey X' disease, responsible for the widespread deaths of turkeys and other poultry throughout Europe due to contaminated Brazilian peanut meal in feed [Asao et al, 1965]. We recently cloned and expressed P4501A5 from turkey liver, which like the human homologue, P4501A2, efficiently epoxidates AFB 1 to produce the exo-AFBO as well as the detoxified metabolite aflatoxin M 1 [Yip and Coulombe, 2006].…”
mentioning
confidence: 99%
“…Aflatoxin B 1 was discovered in the early 1960s as the etiological agent of 'Turkey X' disease, responsible for the widespread deaths of turkeys and other poultry throughout Europe due to contaminated Brazilian peanut meal in feed [Asao et al, 1965]. We recently cloned and expressed P4501A5 from turkey liver, which like the human homologue, P4501A2, efficiently epoxidates AFB 1 to produce the exo-AFBO as well as the detoxified metabolite aflatoxin M 1 [Yip and Coulombe, 2006].…”
mentioning
confidence: 99%
“…The small coupling constant and the large difference in their chemical shifts indicate they are located on a highly polarized Z-olefin. This suggested the presence of the bis-dihydrofuran moiety, typical of the aflatoxins (15). Such a structure also accounts for two low-field singlets at 6 6.44 and 6.46.…”
Section: Discussionmentioning
confidence: 87%
“…The discovery that the toxins had a characteristic fluorescence pattern on thin-layer chromatograms greatly facilitated their isolation and characterization, culminating in the determination of the molecular formulas of four components designated as aflatoxins Bi, B2, Gi, and G2; the four components were distinguished by their blue or green fluorescence and by their Rf values on thin-layer chromatograms (87). More recently, related substances have been isolated and chemically characterized, the most important ones being Mi, M2, B2, and G2a (63).…”
Section: Identification and Characterization Of Aflatoxinsmentioning
confidence: 99%