The Structure of the Flowers of <i>Datura Stramonium</i> L. and <i>D. Tatula</i> L

Wallis, T. E.; Rohatgi, Soma

doi:10.1111/j.2042-7158.1952.tb13139.x

Cited by 5 publications

(1 citation statement)

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“…In both conditions the reactivity of the amino groups was, in decreasing order: a-amino group, lysine 56 I:IGURIS 2 Amino acid sequence of bGll (Santonib ct al., 1976), based on SantoniC ct al. (1 97 1) and revisions: SantomC et al (1973); Wallis (1973). Phcnylalanine was taken as the Nterminus because it is the first amino acid residue in most of the mammalian growth hormones that have been studied and because alanine precedes phenylalanine only in half of the molecules of bG t 1.…”

Section: A R G -A R G -P H E -G L Y -G L U -A L a -S E R -C Y S -A L mentioning

confidence: 99%

MODIFICATION OF LYSINE 69 REACTIVITY IN BOVINE GROWTH HORMONE BY CARBAMYLATION OF ITSN‐TERMINAL GROUP

Nowicki¹,

Santomé²

1981

International Journal of Peptide and Protein Research

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Bovine growth hormone was carbamylated under conditions that assure full reaction of the N‐terminal residue. Approximately 28% of lysine 179 and 7% of lysine 143 were also carbamylated. The modified hormone retained an important growth promoting activity and was as effective as the native hormone in competition assays in vivo for the receptors in rat liver. However, a change in its conformation must occur since lysine 69, which is resistant to trinitropheny‐ lation in the native hormone, reacted easily and under mild conditions, in the carbamylated protein. The growth promoting activity and binding properties of the carbamylated and trinitrophenylated hormone were practically nil.

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Section: A R G -A R G -P H E -G L Y -G L U -A L a -S E R -C Y S -A L mentioning

confidence: 99%