Given a topological dynamical system (X, T ) and an arithmetic function u : N → C, we study the strong MOMO property (relatively to u) which is a strong version of u-disjointness with all observable sequences in (X, T ). It is proved that, given an ergodic measure-preserving system (Z, D, κ, R), the strong MOMO property (relatively to u) of a uniquely ergodic model (X, T ) of R yields all other uniquely ergodic models of R to be u-disjoint. It follows that all uniquely ergodic models of: ergodic unipotent diffeomorphisms on nilmanifolds, discrete spectrum automorphisms, systems given by some substitutions of constant length (including the classical Thue-Morse and Rudin-Shapiro substitutions), systems determined by Kakutani sequences are Möbius (and Liouville) disjoint. The validity of Sarnak's conjecture implies the strong MOMO property relatively to µ in all zero entropy systems, in particular, it makes µ-disjointness uniform. The absence of strong MOMO property in positive entropy systems is discussed and, it is proved that, under the Chowla conjecture, a topological system has the strong MOMO property relatively to the Liouville function if and only if its topological entropy is zero.Measure-theoretic viewpoint While often one focuses on proving the Möbius disjointness for a particular class of zero entropy dynamical systems (see the bibliography in [40]), our approach is more abstract and concentrates on the measure-theoretic aspects. The starting point for us is the following: