The structure and function of the nasopharyngeal lymphoid tissue with special reference to the aetiology of secretory otitis

Gerwat, John

doi:10.1017/s0022215100080221

Cited by 16 publications

(7 citation statements)

References 6 publications

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“…SOM has been shown to be associated with an increased lymphocyte activity measured as spontaneous DNA synthesis (18); in addition an increased fraction of B lymphocytes and an increased CD4/CD8 ratio among adenoid lymphocytes have been shown to be associated with SOM and/or recurrent upper respiratory infection ( 1 7). A study comparing follicle size in adenoids from SOM children with those from children without ear disease revealed no differences (5).…”

mentioning

confidence: 95%

Adenoid tissue lymphocyte subpopulations - evaluation of a quantitative analysis with flow cytometry

Hemlin

Carenfelt

Halldén

et al. 1993

Apmis

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Secretory otitis media (SOM) is a common childhood disease without a completely clarified etiology. A chronic inflammatory condition in the nasopharynx, presumably caused by an increased bacterial load, is one factor of probable etiological importance. In the present study a flow cytometric method for analysis of adenoid lymphoid cell populations was developed to facilitate quantitative comparisons between children with SOM and children without ear disease. Adenoids removed from 18 children due to adenoid hyperplasia and obstructive symptoms were studied. Results of the flow cytometric analysis correlated well with the findings from immunohistological studies of five of the adenoids. PCA‐1 and CD25 were found to be good markers of increased cellular activity after non‐specific stimulation in cell culture. It is concluded that the flow cytometric method is suitable for further quantitative analysis of adenoid tissue.

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mentioning

confidence: 95%

Adenoid tissue lymphocyte subpopulations - evaluation of a quantitative analysis with flow cytometry

Hemlin

Carenfelt

Halldén

et al. 1993

Apmis

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“…Aus anatomischer Sicht ist dieser Argumentation allerdings nur schwer zu folgen, da die funktionell wichtigen Muskelabschnitte auûerhalb des Nasopharynx liegen.SadØ und Luntz sehen bei der Adenotomie ebenfalls nur einen geringen Einfluss auf die Tubenfunktion, weil nach ihren Studien Paukenröhrchen die Mittelohrbelüftung und die audiologischen Ergebnisse wesentlich stärker beeinflussen als die Adenotomie[119]. In anderen Untersuchungen wurde keine Korrelation zwischen Gröûe und Gewicht von Adenoiden und sekretorischer Otitis media gefunden[120,127].…”

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Morphologie, Funktion und Klinik der Tuba Eustachii

Pahnke¹

2000

Laryngorhinootologie

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Morphology, Function, and Clinic of the Eustachian Tube. Diagnostic and treatment of diseases of the Eustachian tube are difficult due to the deep position underneath the skull base and its oblique course. Several theories exist explaining the normal and disturbed function. Few sufficient tests for functional evaluation exist. Gross anatomical and microscopical features of the Eustachian tube gained from 30 sectional series were correlated with radioanatomical findings of high resolution magnetic resonance tomography (MRT) of 29 adult persons without ear disease. Differences to MRT of 31 patients with tubal disease or disturbed ear ventilation were evaluated. Tubal cartilage (TC), musculus tensor veli palatini (MTVP), and Ostmanns fat pad have a characteristical shape, that is correlated to normal function. The zone of physiological tubal closure is found in the vicinity of the isthmus. For precise imaging of these anatomical tubal structures using of special simple or double angulation of MRT-planes is necessary. Open tube disease often shows a typical atrophy of the Ostmans fat pad in the physiological closing zone. Causes of obstruction are found in different parts of the tube. Atrophy and hypertrophy of mucous membrane are also shown as a pathogenetic factor. In many cases disturbed function of the Eustachian tube is correlated to impaired anatomical structures which may be identified by MRT. Treatment should be planned according to afflicted structures. A synopsis of anatomy, physiology, and clinical characteristics is presented.

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“…Umfangreiche Untersuchungen weisen jedoch daraufhin, dass eine solche Vorstellung zu einfach und das isolierte mechanische Hindernis hyperplastischer Rachenmandeln für die Entstehung eines chronischen Paukenergusses von eher untergeordneter Bedeutung ist [16 ± 20]. Vergleichende Arbeiten zu Gewicht und Gröûe abgetragener Rachenmandeln zwischen Kindern mit chronischem Paukenerguss und gesunden Kindern konnten in diesem Zusammenhang hinsichtlich der o. g. Parameter ebenso keinen Unterschied zeigen [21,22].…”

Section: Pathogenese Des Chronischen Paukenergussesunclassified

Stand der kontroversen Diskussion um die Pathogenese und Behandlung des chronischen Paukenergusses im Kindesalter

Dünne¹,

Werner²

2001

Laryngorhinootologie

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The structure and function of the nasopharyngeal lymphoid tissue with special reference to the aetiology of secretory otitis

Cited by 16 publications

References 6 publications

Adenoid tissue lymphocyte subpopulations - evaluation of a quantitative analysis with flow cytometry

Adenoid tissue lymphocyte subpopulations - evaluation of a quantitative analysis with flow cytometry

Morphologie, Funktion und Klinik der Tuba Eustachii

Stand der kontroversen Diskussion um die Pathogenese und Behandlung des chronischen Paukenergusses im Kindesalter

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